Advancement of studies on radionuclide imaging of receptor transgenes

WANG Zhe                 WANG Jing

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Advancement of studies on radionuclide imaging of receptor transgenes

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- Advancement of studies on radionuclide imaging of receptor transgenes
- NUCLEAR TECHNIQUES Issue 6, (2004)
- 作者机构：
  
  1. 西安第四军医大学第一附属医院核医学科
  2. 西安第四军医大学第一附属医院核医学科,西安,710032
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 June 2004
- 稿件说明：
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[1]王喆,汪静.受体转基因显像研究现状与进展[J].核技术,2004(06):461-463.

WANG Zhe WANG Jing. Advancement of studies on radionuclide imaging of receptor transgenes[J]. Nuclear techniques, 2004, (6): 461-463.
[1]王喆,汪静.受体转基因显像研究现状与进展[J].核技术,2004(06):461-463. DOI：

WANG Zhe WANG Jing. Advancement of studies on radionuclide imaging of receptor transgenes[J]. Nuclear techniques, 2004, (6): 461-463. DOI：

摘要

由于无法监控转基因的定位、表达定量、持续时间;因而基因治疗计划的进程受到了限制。随着受体显像的发展与分子生物学技术的进步;产生了报告基因/报告探针技术;为监测基因治疗效果提供了良好途径。本文主要综述了受体基因作为报告基因与治疗基因共同转基因并通过放射性核素显像监测表达的方法。

Abstract

Gene therapy protocols are hampered by the inability to monitor the location

magnitude

duration of transferred gene expression. With the progress of receptor imaging technology and molecule-biology

a new technic— reporter gene/imaging probe technic comes up

which becomes a good approach to monitor the gene transfer therapeutic efficacy. In the paper we review several strategies to monitor the gene therapeutic efficacy by certain receptor gene as reporter gene transferred together with therapeutic gene through radionuclide imaging.

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