Preparation of <sup>99</sup>Tc<sup>m</sup>-DTPA-Folate and biodistribution study in athymic mice

WAN Danjing ZHONG Gaoren XU Peikang ZHU Jianhua

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Preparation of ⁹⁹Tc^m-DTPA-Folate and biodistribution study in athymic mice

更新时间：2021-03-12

- Preparation of ⁹⁹Tc^m-DTPA-Folate and biodistribution study in athymic mice
- NUCLEAR TECHNIQUES Issue 4, (2004)
- 作者机构：
  
  1. 复旦大学药学院放射药学教研室
  2. 复旦大学药学院放射药学教研室,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC： R73-3
- Published：01 April 2004
- 稿件说明：
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[1]万丹晶,钟高仁,徐培康,朱建华.~(99)Tc~m-DTPA-Folate的制备及其荷瘤裸鼠体内分布[J].核技术,2004(04):293-296.

WAN Danjing ZHONG Gaoren XU Peikang ZHU Jianhua. Preparation of ⁹⁹Tc^m-DTPA-Folate and biodistribution study in athymic mice[J]. Nuclear techniques, 2004, (4): 293-296.
[1]万丹晶,钟高仁,徐培康,朱建华.~(99)Tc~m-DTPA-Folate的制备及其荷瘤裸鼠体内分布[J].核技术,2004(04):293-296. DOI：

WAN Danjing ZHONG Gaoren XU Peikang ZHU Jianhua. Preparation of ⁹⁹Tc^m-DTPA-Folate and biodistribution study in athymic mice[J]. Nuclear techniques, 2004, (4): 293-296. DOI：

摘要

制备了Tcm-DTPA-Folate并对其在荷瘤裸鼠的体内分布进行了初步探索。将叶酸（Folate）与DTPA99连接

合成DTPA-Folate

再用Tcm标记

考察标记物的纯度和稳定性

并进行荷人SGC-7901胃癌肿瘤裸99鼠的体内分布特性研究。结果表明

99Tcm-DTPA-Folate的标记率>98%。标记物室温放置4h

放化纯度>90%。裸鼠腹腔注射99Tcm-DTPA-Folate后8h

肿瘤与周围肌肉的含量比值高达7.5:1。

Abstract

The purpose of this article is to study the preparation and biodistribution of Tcm-DTPA-folate in nude 99 mice with a human tumor cell implant. DTPA-folate was synthesized by conjugating folic acid to diethylenetriaminepentaacetic(DTPA)

then radiolabeled with 99Tcm. The radio-chemical purity and stability were evaluated. The biodistribution of Tcm-DTPA-folate in nude mice with a human tumor cell implant was studied. The 99 result showed that the radiolabelling yield of Tcm-DTPA-folate was as high as 98%. After 4 h at room temperature

99 the radiochemical purity of Tcm-DTPA-folate was still over 90%. Tcm-DTPA-folate conjugation showed marked 99 99 tumor-specific deposition in vivo. The tumor-to-muscle ratio at 8 h post intraperitoneal injection was 7.5. 99Tcm-DTPA-folate appears to be a potential radiopharmaceutical for targeting tumor-associated folate receptor.

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Related Author

沈海星

杨阳

钱隽

朱建华

2 ZHU Jianhua 1 QIAN Jun 1 YANG Yang 1 SHEN Haixing 1 1

GUO Congying 1 ZHANG Zhengwei 1

李晓敏

罗世能

Related Institution

复旦大学华山医院PET中心

School of Pharmacy,Fudan University,Shanghai 200032,China) 2

中国药科大学

Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health, Wuxi 214063, China) 2

Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Ministry of Health, Wuxi 214063, China) 2

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Preparation of 99Tcm-DTPA-Folate and biodistribution study in athymic mice

DOI：

摘要

Abstract

关键词

Keywords

references

Preparation of ⁹⁹Tc^m-DTPA-Folate and biodistribution study in athymic mice