Monte Carlo simulation and analysis of energetic particles’ implantation damage to the tumor cells in BNCT

JIANG Haiyan1; 2 WU Yican1 ARTS Team1     1

doi:null

您当前的位置：

首页 >

文章列表页 >

Monte Carlo simulation and analysis of energetic particles’ implantation damage to the tumor cells in BNCT

更新时间：2021-03-12

- Monte Carlo simulation and analysis of energetic particles’ implantation damage to the tumor cells in BNCT
- NUCLEAR TECHNIQUES Issue 9, (2004)
- 作者机构：
  
  1. 中国科学院等离子体物理研究所
  2. 中国科学院等离子体物理研究所,合肥,230031
  3. 合肥工业大学理学院合肥,230009
  4. ,合肥,230031
- 作者简介：
- 基金信息：
  
  安徽省自然科学基金(01043601);中国科学院等离子体物理研究所所长基金资助
- DOI：
  CLC： R730.5
- Published：01 September 2004
- 稿件说明：
移动端阅览
[1]江海燕,吴宜灿,ARTS课题组.BNCT中载能粒子对肿瘤细胞损伤效应的Monte Carlo模拟及分析[J].核技术,2004(09):687-692.

JIANG Haiyan1, 2 WU Yican1 ARTS Team1 1. Monte Carlo simulation and analysis of energetic particles’ implantation damage to the tumor cells in BNCT[J]. Nuclear techniques, 2004, (9): 687-692.
[1]江海燕,吴宜灿,ARTS课题组.BNCT中载能粒子对肿瘤细胞损伤效应的Monte Carlo模拟及分析[J].核技术,2004(09):687-692. DOI：

JIANG Haiyan1, 2 WU Yican1 ARTS Team1 1. Monte Carlo simulation and analysis of energetic particles’ implantation damage to the tumor cells in BNCT[J]. Nuclear techniques, 2004, (9): 687-692. DOI：

摘要

为更好地了解硼中子俘获治疗（Boronneutroncapturetherapy

BNCT）中载能粒子穿过单个细胞引起的生物学效应以及理解在细胞或亚细胞水平上的微观剂量分布

采用MonteCarlo程序模拟载能粒子在人体细胞中的输运过程

给出了α粒子垂直细胞表面入射时的射程分布、径迹结构及靶损伤情况

同时模拟分析了10B位于细胞中不同位置时主要载能粒子（α粒子和Li离子）在细胞中能量沉积情况和相应的细胞损伤与存7活情况

为BNCT的微剂量研究提供了初步的理论依据。

Abstract

In this paper

the interaction between energetic particles and tumor cell in BNCT (Boron Neutron Capture Therapy) has been simulated by SRIM code based on Monte-Carlo simulation.The distribution and track of particles as well as the damage of the target have been presented when α-particle implantation to tumor cell perpendicularly from the cell membrane.The deposited energy of the energetic particles produced from the B(n

10 α)7Li neutron capture reaction in different situations of the cell model is also calculated and the computed results are analyzed using cell survival curves.The conclusion may be important to understand the biological effect of single particle and the distribution of microdosimetry at cellular and subcellular level.In addition

it would provide elementary theory for microdosimetry of BNCT.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Physical study of a high-energy proton degrader

Performance simulation of a Shashlik sampling electromagnetic calorimeter for NICA-MPD

Physical study on target area of simplified experimental muon source at CSNS

Monte Carlo simulation of dose enhancement effect of X-ray at Au/Si interface

Simulation study of neutrons time-correlated coincidence count for uranium components based on ²⁵²Cf source-driven noise analysis method

Related Author

MU Qili

DONG Qifan

JING Hantao

ZENG Dekai

PENG Xiaoyu

WEI Xin

CHENG Kai

JI Xuantao

Related Institution

Spallation Neutron Source Science Center

Institute of High Energy Physics, Chinese Academy of Sciences

School of Nuclear Science and Technology, University of South China

Jilin University

新疆大学物理科学与技术学院

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881077 Visits Today：604

⁰