Study of zinc elemental distribution in mouse brain by SRXRF

ZHANG Yuanxun WANG Yinsong LI Delu     LI Aiguo ZHANG Guilin

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Study of zinc elemental distribution in mouse brain by SRXRF

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- Study of zinc elemental distribution in mouse brain by SRXRF
- NUCLEAR TECHNIQUES Issue 9, (2004)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 第二军医大学军队卫生教研室
  3. 中国科学院高能物理研究所,上海,201800
  4. ,北京,100039
- 作者简介：
- 基金信息：
  
  国家自然科学基金(10175085);北京正负电子对撞机国家实验室项目(03025)资助
- DOI：
  CLC： R151
- Published：01 September 2004
- 稿件说明：
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[1]张元勋,王荫淞,李德禄,李爱国,张桂林,龙建纲,王福俤,沈慧,秦海宏,黄宇营,何玮.同步辐射X荧光方法用于鼠脑锌元素分布的研究[J].核技术,2004(09):655-659.

ZHANG Yuanxun WANG Yinsong LI Delu LI Aiguo ZHANG Guilin. Study of zinc elemental distribution in mouse brain by SRXRF[J]. Nuclear techniques, 2004, (9): 655-659.
[1]张元勋,王荫淞,李德禄,李爱国,张桂林,龙建纲,王福俤,沈慧,秦海宏,黄宇营,何玮.同步辐射X荧光方法用于鼠脑锌元素分布的研究[J].核技术,2004(09):655-659. DOI：

ZHANG Yuanxun WANG Yinsong LI Delu LI Aiguo ZHANG Guilin. Study of zinc elemental distribution in mouse brain by SRXRF[J]. Nuclear techniques, 2004, (9): 655-659. DOI：

摘要

为了探索锌等金属元素在脑中的精细分布与ZnT3mRNA表达之间的相互作用和功能

本项研究使用同步辐射X射线荧光技术（SRXRF）测定小鼠全脑和脑切片中锌等金属元素的分布

同时使用反转录多聚酶链式反应（RT-PCR）检测小鼠各组织中的ZnT3mRNA的表达量。分析结果表明

脑中锌元素不是均匀分布的

主要分布在皮层、海马和齿状回部位

它们的锌浓度比道束区高出5—10倍。与此结果相对应的是大脑皮层、海马和睾丸中的ZnT3mRNA有较高丰度

而其他组织中未检出ZnT3mRNA。进一步的推断提示ZnT3能促进胞浆内的锌富集于神经元囊泡中

通过介导胞浆锌的跨膜转运过程构造囊泡的“锌池”。

Abstract

In order to explore the function and interaction between the ZnT3 mRNA expression and elemental zinc distribution in mouse brain slice

zinc concentration and its distribution were determined by SRXRF and ZnT3 mRNA expression in organs was examined by RT-PCR method. The analysis results show that the zinc content is not evenly distributed. The zinc content in cerebral cortex and hippocampus is nearly 5—10 times higher than that in other positions. Correspondingly

ZnT3 mRNA in cerebral cortex

hippocampus and testis has higher abundance

but it can not be examined out in other organs. Furthermore

the results suggest that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play important roles in the structuring of vesicular zinc pool.

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