A simplified method for preparation and identification of radio-iodinated IBZM

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A simplified method for preparation and identification of radio-iodinated IBZM

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- A simplified method for preparation and identification of radio-iodinated IBZM
- NUCLEAR TECHNIQUES Issue 4, (2000)
- 作者机构：
  
  华西医科大学附属第一医院,成都,610041
- 作者简介：
- 基金信息：
  
  卫生部科研基金!94－2－166
- DOI：
  CLC： R817
- Published：01 April 2000
- 稿件说明：
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[1]曹国祥,谭天秩,梁正路.放射性碘化IBZM的快速制备及鉴定[J].核技术,2000(04):247-252.

A simplified method for preparation and identification of radio-iodinated IBZM[J]. Nuclear techniques, 2000, (4): 247-252.
[1]曹国祥,谭天秩,梁正路.放射性碘化IBZM的快速制备及鉴定[J].核技术,2000(04):247-252. DOI：

A simplified method for preparation and identification of radio-iodinated IBZM[J]. Nuclear techniques, 2000, (4): 247-252. DOI：

摘要

采用自行设计的低浓度过氧化氢乙酸法碘化标记（ｓ）－ＢＺＭ，Ｓｅｐ－ＰａｋＣ１８小柱分离纯化反应产物，无菌无热原滤器除菌。结果表明低浓度过氧化氢乙酸法是最佳的碘化标记（ｓ）－ＢＺＭ的方法，其碘化标记率≥９０％，无副产物，易于进行无菌无热原处理。纯化产物的放射化学纯度为９６.８％±１．４％（ｎ＝５），全程产率为８１．９％±２．８％（ｎ＝５）。由此可见采用低浓度过氧化氢乙酸法，配合Ｓｅｐ—ＰａｋＣ

１８

小柱分离纯化和无菌无热原滤器除菌，能简便、快速、高产率地制备无菌无热原的放射性碘化ＩＢＺＭ，是极具实用的临床方法。

Abstract

(s)-BZM { （s）- （-）-2-hydroxy-3-6-methoxy-N- [（1-ethyl-2-pyrrodinyl） methyl] benzamide} was labelled with radio-iodine by low concentration hydrogen peroxide plus acetic acid （LCHPPAA） as oxidant

The radio-iodinated IBZM was separated by Sep-Pak C

cartridge. The results showed that the LCHPPAA was a superior oxidant for preparation of radio-iodinated IBZM. This process had no by-products and its labelling yield was ≥90%. The radiochemical purity of purified products was 96.8% ±1.4% （n= 5）. The overall yield of the radio-iodinated IBZM prepared by this method was 81.9%±2.8% （n=5）. Therefore

the LCHPPAA labelling technique and the Sep-Pak C

cartridge purification method was very useful for the preparation of radio-iodinated IBZM in clinical application.

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