Application of somatostatin and their analogues in nuclear medicine

WANG Lihua   WANG Yongxian   YIN Duanzhi

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Application of somatostatin and their analogues in nuclear medicine

更新时间：2021-03-12

- Application of somatostatin and their analogues in nuclear medicine
- NUCLEAR TECHNIQUES Issue 7, (2003)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 中国科学院上海原子核研究所,上海,201800
- 作者简介：
- 基金信息：
  
  国际原子能机构(IAEA)资助项目(No.9570/R0);中国科学院知识创新重大项目(KJCXI-SW-08)
- DOI：
  CLC： R817
- Published：01 July 2003
- 稿件说明：
移动端阅览
[1]王丽华,汪勇先,尹端沚.生长抑素及其类似物的标记技术的发展[J].核技术,2003(07):537-544.

WANG Lihua WANG Yongxian YIN Duanzhi. Application of somatostatin and their analogues in nuclear medicine[J]. Nuclear techniques, 2003, (7): 537-544.
[1]王丽华,汪勇先,尹端沚.生长抑素及其类似物的标记技术的发展[J].核技术,2003(07):537-544. DOI：

WANG Lihua WANG Yongxian YIN Duanzhi. Application of somatostatin and their analogues in nuclear medicine[J]. Nuclear techniques, 2003, (7): 537-544. DOI：

摘要

生长抑素受体显像剂是临床上应用最为普遍的放射性多肽类受体显像剂。用多种放射性同位素111In、90Y、67Ga、68Ga、64Cu或是用99Tcm、188Re以及卤族同位素123I、18F等对奥曲肽及其类似物进行标记得到的放射性多肽药物

已广泛用于临床显像。介绍了生长抑素类似物及标记技术的发展

对目前临床上比较成熟的生长抑素类显像剂做了综述和比较。同时介绍了目前在SST类似物开发领域及生物行为研究领域中的最新发展动态。

Abstract

Receptor targeting with radiolabeled peptides has become very important in nuclear oncology in the past few years. The most frequently used peptides in the clinic are analogs of somatostatin

e.g. octreoscan

which contain chelators for the radioisotopes 111In

90Y

67Ga

68Ga and 64Cu or for 99Tcm and 188Re

and are labeled with the halogens 123I and 18F. Somatostatin analogs and their radiolabeling are introduced in this article

and the most frequently used somatostatin analog imaging agents are reviewed. In addition

some important developments in exploiting these agents are presented too.

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