Induence of 153Sm-EDTMP and 89SrCl2 on immune function in patients with multiple bone metastases

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Induence of ¹⁵³Sm-EDTMP and ⁸⁹SrCl₂ on immune function in patients with multiple bone metastases

更新时间：2021-03-12

- Induence of ¹⁵³Sm-EDTMP and ⁸⁹SrCl₂ on immune function in patients with multiple bone metastases
- NUCLEAR TECHNIQUES Issue 5, (2000)
- 作者机构：
  
  1. 中山医科大学肿瘤医院,广州,510060
  2. 上海科兴药业公司
- 作者简介：
- 基金信息：
- DOI：
  CLC： R738.1
- Published：01 May 2000
- 稿件说明：
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[1]樊卫,曾宗渊,罗国平,许光普.钐153-乙二胺四甲撑膦和氯化锶对多发性骨转移瘤患者免疫状态的影响[J].核技术,2000(05):329-333.

Induence of ¹⁵³Sm-EDTMP and ⁸⁹SrCl₂ on immune function in patients with multiple bone metastases[J]. Nuclear techniques, 2000, (5): 329-333.
[1]樊卫,曾宗渊,罗国平,许光普.钐153-乙二胺四甲撑膦和氯化锶对多发性骨转移瘤患者免疫状态的影响[J].核技术,2000(05):329-333. DOI：

Induence of ¹⁵³Sm-EDTMP and ⁸⁹SrCl₂ on immune function in patients with multiple bone metastases[J]. Nuclear techniques, 2000, (5): 329-333. DOI：

摘要

为探讨钐１５３－乙二胺四甲撑膦酸(

１５３

Ｓｍ－ＥＤＴＭＰ)和氯化锶(

８９

ＳｒＣｌ

２

)对多发性骨转移瘤患者免疫状态的影响，用

１５３

Ｓｍ－ＥＤＴＭＰ和

８９

ＳｒＣｌ

２

治疗多发性骨转移瘤病人８６例。分别测定患者外周血红细胞、白细胞、Ｔ淋巴细胞亚群和血清中免疫球蛋白的含量及肿瘤坏死因子水平。结果表明，单次

１５３

Ｓｍ－ＥＤＴＭＰ和

８９

ＳｒＣｌ

２

治疗多发性骨转移瘤患者外周血红细胞、Ｔ淋巴细胞亚群和血清中免疫球蛋白的含量及肿瘤坏死因子水平治疗前后和两治疗组之间比较无显著差异（Ｐ＜０．０５），白细胞虽有下降，但仍在正常范围内；随着药物放射剂量增加，病人骨髓毒性增大，外周血红细胞、白细胞和血清中免疫球蛋白的含量降低，而Ｔ淋巴细胞亚群的分布未见变化，说明常规用量的

１５３

Ｓｍ－ＥＤＴＭＰ和

８９

ＳｒＣｌ

２

对患者的Ｔ淋巴细胞亚群、免疫球蛋白及肿瘤坏死因子水平等无明显影响，但随着放射性剂量的增加，病人的免疫功能受到影响难以避免，并可能以体液免疫首先受到抑制。

Abstract

To investigate the influence of

153

Sm-EDTMP and

SrCl

on immune function in patients with multiple bone metastate. 86 cases of multiple bone metastases were treated with

153

Sm-EDTMP and

SrCl

during the period of 1995-1998. The patient’s RBC

WBC

T lymphocyte subset

blood immunoglobulin and tumor necrosis factor（TNF） were also measured. Difference in the RBC

T lymphocyte subset

and immunoglobulin and TNF before and after therapy and also between

153

Sm-EDTMP and

SrCl

group both was not significant （P

0.05）. Althrough the WBC have decreased

but still within normal range. As the dose of

153

Sm-EDTMP increased

the toxicity of bone narrow rose then the WBC and RBC of patient and blood IgG decreased

however

T lymphocyte subset has not changed. Common dosage of

153

sm-EDTMP and

SrCl

did not influence patient’s immune function significantly. However with the increasing of therapeutic dose it’s inevitable to influence their immune function and possible to effect the humonal function first.

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The School of Physics & Engineering of Zhongshan University, Guangzhou 510275, China ) 2

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Department of Nuclear Medicine, Jiaozuo People’s Hospital

河南省焦作市人民医院核医学科

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