Studies on mRNA expression of the somatostatin receptor family in breast cancer

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Studies on mRNA expression of the somatostatin receptor family in breast cancer

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- Studies on mRNA expression of the somatostatin receptor family in breast cancer
- NUCLEAR TECHNIQUES Issue 11, (1999)
- 作者机构：
  
  1. 第四军医大学西京医院!西安７１００３２
  2. 沈阳军区２０２医院!沈阳１１００００
  3. 第四军医大学!西安７１００３２
- 作者简介：
- 基金信息：
  
  国家青年自然科学基金!39500035
- DOI：
  CLC： R737.9
- Published：01 November 1999
- 稿件说明：
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[1]汪静,金河天,王连刚,武胜昔,邓敬兰.原发性乳腺癌SSTR1-3mRNA分布特性的研究[J].核技术,1999(11):651-654.

Studies on mRNA expression of the somatostatin receptor family in breast cancer[J]. Nuclear techniques, 1999, (11): 651-654.
[1]汪静,金河天,王连刚,武胜昔,邓敬兰.原发性乳腺癌SSTR1-3mRNA分布特性的研究[J].核技术,1999(11):651-654. DOI：

Studies on mRNA expression of the somatostatin receptor family in breast cancer[J]. Nuclear techniques, 1999, (11): 651-654. DOI：

摘要

为研究生长抑素受体三种亚型（ＳＳＴＲ１－３）在原发性乳腺癌中的分布特性，以［０６３３α－３５Ｓ］ｄＡＴＰ标记ＳＳＴＲ三种亚型的寡核昔酸为探针，运用原位杂交技术，检测１０例乳腺癌组织中ＳＳＴＲ１—３ｍＲＮＡ的表达模式，并用Ｌｅｉｃａ图像分析仪对表达密度作半定量分析。结果表明，ＳＳＴＲ１—３在乳腺癌中的表达模式以表达ＳＳＴＲ２为主（７／１０）；从ＳＳＴＲ１—３在乳腺癌中的表达密度看，ＳＳＴＲ２高于其它两种亚型（８２．３±１．４）；与ＳＳＴＲ１、３相比，ＳＳＴＲ２为优势表达亚型（Ｐ＜０．０１）．说明ＳＳＴＲ３种亚型在乳腺癌中可同时表达，其分布模式呈异质性，其表达模式存在着较大的个体差异，从表达率及表达密度的半定量分析来看，ＳＳＴＲ２均为主要表达亚型，提示乳腺癌具有接受生长抑素类似物靶向药物治疗的乐观前景。

Abstract

The objective of this paper is to investigate the characteristics of expression anddistribution of 3 subtypes of somatostatin receptors (SSTRI-3) in breast cancer.With [a-~35S] dATP labeled oligonucleotide of the 3 SSTR subtypes as probe

using insitu hybridization

patterns of mRNA expression were detected in 10 breast cancercases. Additionally

semi-quantitative analysis of the densities of the expression wereestimated by a compreterized image-analysis system. Patterns of SSTR1-3expression in breast cancer were as follows: SSTR2 expression was dominant in 10cases than that of the other 2 subtypes; Therefore

it has positive prospects forsomatostatin analog-oriented agents to be used in treatment of breast cancers.

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Related Author

李焰

邓敬兰

汪静

LI Fujun WANG Jing DENG Jinglan

Mengzhi ZHANG

Qing ZHANG

Xuezhong CHEN

Related Institution

第四军医大学口腔医院

Xijing Hospital, Fourth Military Medical University, Xi’an 710032) LI Yan

Department of Nuclear Medicine, the First Affiliated Hospital of Nanchang University

School of Medicine,Tsinghua University

复旦大学上海医学院肿瘤学系

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