Syntheses of [2-<sup>15</sup>N] tryptamine and [2-<sup>15</sup>N] perlolyrine

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Syntheses of [2-¹⁵N] tryptamine and [2-¹⁵N] perlolyrine

更新时间：2021-03-12

- Syntheses of [2-¹⁵N] tryptamine and [2-¹⁵N] perlolyrine
- NUCLEAR TECHNIQUES Issue 8, (1999)
- 作者机构：
  
  1. 中国医学科学院-中国协和医科大学北京协和医院,北京
  2. ,100730
- 作者简介：
- 基金信息：
  
  国家自然科学基金;高等学校博士学科点专项科研基金
- DOI：
  CLC： R914
- Published：01 August 1999
- 稿件说明：
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[1]唐刚华,王世真,姜国辉.~(15)N_b—色胺和[2—~(15)N]川芎哚的合成[J].核技术,1999(08):504-507.

Syntheses of [2-¹⁵N] tryptamine and [2-¹⁵N] perlolyrine[J]. Nuclear techniques, 1999, (8): 504-507.
[1]唐刚华,王世真,姜国辉.~(15)N_b—色胺和[2—~(15)N]川芎哚的合成[J].核技术,1999(08):504-507. DOI：

Syntheses of [2-¹⁵N] tryptamine and [2-¹⁵N] perlolyrine[J]. Nuclear techniques, 1999, (8): 504-507. DOI：

摘要

以[α-15N]甘氨酸为起始原料经7步反应合成15b-色胺，产率为45％。以制备的15Nb-色胺为原料经3步反应合成[2－15N]川芎哚，产率为22．2％。标记川芎哚经衍生化后用GC－MS测得15N丰度大于90％。结果表明，合成的标记物满足药物代谢研究的需要。

Abstract

15Nb-tryptamine was synthesized starting from [a -15N] glycine via 7 steps. Theyield of 15Nb-tryptamine from [a -15N] glycine was 45%. [2-15N] perlolyrine wassynthesized from 15Nb-tryptamine via 3 steps

the yield of [2-15N] perlolyrine from15Nb-tryptamine was 22.2%. The 15N abundance of [2-15N] perlolyrine was morethan 90%. The synthetic showed that the synthetic compounds were suitable for thestuding of drug metabolism.

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Syntheses of [2-15N] tryptamine and [2-15N] perlolyrine

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摘要

Abstract

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Syntheses of [2-¹⁵N] tryptamine and [2-¹⁵N] perlolyrine