A study on preparation of <sup>188</sup>Re-HEDP

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A study on preparation of ¹⁸⁸Re-HEDP

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- A study on preparation of ¹⁸⁸Re-HEDP
- NUCLEAR TECHNIQUES Issue 6, (1999)
- 作者机构：
  
  1. 中国科学院上海原子核研究所,上海
  2. ,201800
  3. 中国科学院上海原子核研究所!上海201800!上海科兴药业公司
  4. 上海科兴药业公司,上海
  5. 中国科学院上
- 作者简介：
- 基金信息：
  
  国际原子能机构基金
- DOI：
  CLC： R817
- Published：01 June 1999
- 稿件说明：
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[1]郭子丽,张炯,闵小锋,于俊峰,李卜森,胡伟青,何蔚瑜,汪勇先.~(188)Re—HEDP的制备研究[J].核技术,1999(06):374-377.

A study on preparation of ¹⁸⁸Re-HEDP[J]. Nuclear techniques, 1999, (6): 374-377.
[1]郭子丽,张炯,闵小锋,于俊峰,李卜森,胡伟青,何蔚瑜,汪勇先.~(188)Re—HEDP的制备研究[J].核技术,1999(06):374-377. DOI：

A study on preparation of ¹⁸⁸Re-HEDP[J]. Nuclear techniques, 1999, (6): 374-377. DOI：

摘要

为了研制一种新型的骨转移疼痛缓解治疗剂－（188）Re－HEDP，合成了配体HEDP，产率大于90％，并用自制（188）W－（188）Re发生器产生的（188）Re标记HEDP。系统地研究了HEDP、SnCl2和VitC的量，溶液pH值，反应温度和反应时间对标记产额的影响。标记物经HPLC和PC检测，放化纯度及标记率大于95％。在体外12h稳定。

Abstract

The development of a new potential bone pain palliation agent

188Re--HEDP

was described here. The ligand HEDP was synthesized giving a yield over 90% and the is8Re--HEDP was prepared with generator--produced 188Re. Labelling yield and radiochemical purity were determined by TLC and HPLC. The optimal labelling conditions were systematically investigated and the kit formulation was developed.The labelling efficiency of 188Re--HEDP was greater than 95%

and the radiochemicalpurity was still over 90% after stored at 15℃ for 12 hrs.

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A study on preparation of 188Re-HEDP

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摘要

Abstract

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references

A study on preparation of ¹⁸⁸Re-HEDP