Hepatic ASGP receptor image of <sup>99m</sup>Tc-NGA in normal rabbit

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Hepatic ASGP receptor image of ^99mTc-NGA in normal rabbit

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- Hepatic ASGP receptor image of ^99mTc-NGA in normal rabbit
- NUCLEAR TECHNIQUES Issue 11, (1999)
- 作者机构：
  
  1. 江苏省原子医学研究所核医学国家重点实验室!无锡２１４０６３
  2. 江苏省原子医学研究所核
- 作者简介：
- 基金信息：
  
  江苏省卫生厅科研基金!149533
- DOI：
  CLC： Q95-3
- Published：01 November 1999
- 稿件说明：
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[1]陶永辉,张荣军,胡名扬,万卫星,谭成,张莲芬,蔡刚明,王博诚,金坚.应用~(99m)Tc-NGA进行肝ASGP受体显像的实验研究[J].核技术,1999(11):663-667.

Hepatic ASGP receptor image of ^99mTc-NGA in normal rabbit[J]. Nuclear techniques, 1999, (11): 663-667.
[1]陶永辉,张荣军,胡名扬,万卫星,谭成,张莲芬,蔡刚明,王博诚,金坚.应用~(99m)Tc-NGA进行肝ASGP受体显像的实验研究[J].核技术,1999(11):663-667. DOI：

Hepatic ASGP receptor image of ^99mTc-NGA in normal rabbit[J]. Nuclear techniques, 1999, (11): 663-667. DOI：

摘要

新半乳糖人血清白蛋白（ＮＧＡ）是肝细胞表面去唾液酸糖蛋白受体（ＡＳＧＰＲ）的特异性配基。根据受体与配基结合的原理，报道了以９９ｍＴｃ标记的ＮＧＡ与人血清白蛋白（ＨＳＡ）在正常兔中显像行为的对比。结果表明９９ｍＴｃ－ＨＳＡ呈现血池显像剂的行为，而９９ｍＴｃ－ＮＧＡ则呈现肝脏受体显像剂的行为，并且若兔事先用１００倍量未标记的ＮＧＡ将肝脏受体饱和后，再用９９ｍＴｃ－ＮＧＡ显像则呈现与９９ｍＴｃ－ＨＳＡ相似的显像结果。以异硫氰酸荧光素标记的ＮＧＡ（ＦＩＴＣ－ＮＧＡ）进行流式细胞分析（ＦＣＭ）也表明，ＡＳＧＰＲ具有明显可饱和性。由此进一步表明９９ｍＴｃ－ＮＧＡ是ＡＳＧＰ受体显像，而非胶体显像；且具有饱和性．

Abstract

Galactosylneoglycoalbumin (NGA) is aspecific ligand of asialoglycoproteinreceptor (ASGPR) in hepatocyte surface.In this paper

the imaging comparison of~99mTc-NGA and ~99mTc-HSA in normal rabbit imaging are reported. ~99mTo-HSAgenerated a blood pool image when injected into normal rabbit

while ~99mTo-NGAshowed a hepatic receptor image charateristics. If rabbit hepatic receptor had beensaturated with 100 times amounts of NGA

~99mTc-NGA would generate a blood poolimaging sunilar to ~99mTc-HSA. Flow cytometry (FCM) analysis with FITC-NGA alsoshowed that ASGPR could be obviously saturated. Therefore

~99mTc-NGA is ahepatic receptor image agent.

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Hepatic ASGP receptor image of 99mTc-NGA in normal rabbit

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摘要

Abstract

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references

Hepatic ASGP receptor image of ^99mTc-NGA in normal rabbit