The preparation of <sup>188</sup>Re labelled Stannic sulfur suspension and preliminary animal experiment

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The preparation of ¹⁸⁸Re labelled Stannic sulfur suspension and preliminary animal experiment

更新时间：2021-03-12

- The preparation of ¹⁸⁸Re labelled Stannic sulfur suspension and preliminary animal experiment
- NUCLEAR TECHNIQUES Issue 11, (1999)
- 作者机构：
  
  1. 中国科学院上海原子核研究所!上海２０１８００
  2. 上海铁路中心医院!上海２０００７２
- 作者简介：
- 基金信息：
- DOI：
  CLC： R943
- Published：01 November 1999
- 稿件说明：
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[1]李惠源,董墨,俎建华,吴元芳,邱桂林,史建国.~(188)Re标记锡硫混悬液的制备及初步动物实验[J].核技术,1999(11):690-694.

The preparation of ¹⁸⁸Re labelled Stannic sulfur suspension and preliminary animal experiment[J]. Nuclear techniques, 1999, (11): 690-694.
[1]李惠源,董墨,俎建华,吴元芳,邱桂林,史建国.~(188)Re标记锡硫混悬液的制备及初步动物实验[J].核技术,1999(11):690-694. DOI：

The preparation of ¹⁸⁸Re labelled Stannic sulfur suspension and preliminary animal experiment[J]. Nuclear techniques, 1999, (11): 690-694. DOI：

摘要

１８８Ｒｅ标记锡硫混悬液经两步制备得到。先用１８８Ｒｅ的高铼酸盐与疏代硫酸钠溶液在明胶及酸性条件下加入氯化亚锡得到酸性的１８８Ｒｅ标记混悬液，然后调ｐＨ至中性而制得１８８Ｒｅ标记锡硫混悬液。混悬液的颗粒度主要为２—５ｕｍ，放化纯度大于９５％，体内、体外稳定性良好。动物实验表明，该混悬液对荷人脑胶质瘤裸鼠的抑瘤率达９０％。

Abstract

~188Re labelled stannic sulfur suspension was prepared with two-steps: At firstacid ~188Re labelled suspension was obtained by adding stannous chloride into acidicsolution of ~188Re perrhenate and sodium thioslphate

then adjust the pH of thesolution to neutral point with NaOH and Na2HPO4 and 188Re labelled stannic sulfursuspension was formed. The particles sizes of this suspension were 2-5 U m mainly.The radiochemical purity was above 95%. The suspension was stable in vitro andvivo tests. Finally

animal experiments observed that the tumor inhibiting rate of this~188Re labelled stannic sulfur suspension was 90% in human glioma bearing nude mice.

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The preparation of 188Re labelled Stannic sulfur suspension and preliminary animal experiment

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摘要

Abstract

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The preparation of ¹⁸⁸Re labelled Stannic sulfur suspension and preliminary animal experiment