Investigation of diphosphonates as bone imaging agents

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Investigation of diphosphonates as bone imaging agents

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- Investigation of diphosphonates as bone imaging agents
- NUCLEAR TECHNIQUES Issue 11, (1999)
- 作者机构：
  
  北京师范大学!北京１００８７５
- 作者简介：
- 基金信息：
- DOI：
  CLC： R981.1
- Published：01 November 1999
- 稿件说明：
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[1]吕恭序,陈红映.二膦酸类骨显像剂的研究[J].核技术,1999(11):682-685.

Investigation of diphosphonates as bone imaging agents[J]. Nuclear techniques, 1999, (11): 682-685.
[1]吕恭序,陈红映.二膦酸类骨显像剂的研究[J].核技术,1999(11):682-685. DOI：

Investigation of diphosphonates as bone imaging agents[J]. Nuclear techniques, 1999, (11): 682-685. DOI：

摘要

研究了１，２－二羟基－１，２－二膦酸乙烷（ＤＨＰＥ）、２，８－二羟基－２，３－二膦酸丁烷（ＤＨＰＢ及２，４－二羟基－２，４－二膦酸戊烷（ＤＨＰＰ）三种络合物的合成并用９９ｍＴｃ标记，研究了影响标记率的因素和标记的最佳方法。对这三种络合物进行了小鼠体内生物分布的对比研究，结果表明３种化合物与９９ｍＴｃ均能很好地络合，并具有亲骨性。

Abstract

2-dihydroxy-1

2-his (dihydroxy phosphonyl) ethane (DHPE)

3-dihydroxy2

3-bis (dihydroxy phosphonyl) butane (DHPB) and 2

4-dihydroxy-2

4-bis(dihydroxy phosphonyl) pentane (DHPP) were synthesized and were labelled by ~99mTc.The influencing factors were studied and the best labelling procedures.were obtained.The biodistribution of ~99mTc-DHPE

99mTc-DHPB and ~99mTc-DHPP in mice wereevaluated. The results of the biodistribution show significant accumulation of all theabove three ligands in mouse bone.

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Synthesis and labelling of a bone imaging agent ^99mTc-HMDP

Related Author

Yiguo Zhou

Liming Wang

Tong Zhu

Huiyang Zhao

Qingxin Shi

Related Institution

Shanghai Medical University

Shanghai Zhongshan Hospital

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