Deuteration of tryptophan and perlolyrine

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Deuteration of tryptophan and perlolyrine

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- Deuteration of tryptophan and perlolyrine
- NUCLEAR TECHNIQUES Issue 9, (1999)
- 作者机构：
  
  1. 中国医学科学院中国协和医科大学北京协和医院,北京
  2. ,100730
- 作者简介：
- 基金信息：
  
  高等学校博士学科点专项科研基金;国家自然科学基金
- DOI：
  CLC： R284
- Published：01 September 1999
- 稿件说明：
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[1]唐刚华,王世真,姜国辉.氘标色氨酸和氘标川芎哚的合成研究[J].核技术,1999(09):573-575.

Deuteration of tryptophan and perlolyrine[J]. Nuclear techniques, 1999, (9): 573-575.
[1]唐刚华,王世真,姜国辉.氘标色氨酸和氘标川芎哚的合成研究[J].核技术,1999(09):573-575. DOI：

Deuteration of tryptophan and perlolyrine[J]. Nuclear techniques, 1999, (9): 573-575. DOI：

摘要

以色氨酸和氘水及色氨酸和氯化氘两种交换反应合成氘标色氨酸，其产率分别为95％和92％，氘标总丰度分别为96．2％和98．5％。以色氨酸和氘水反应合成的氘标色氨酸为原料，经环化、氧化脱羧及水解等反应合成氘标川芎哚，产率为11．6％，氘标总丰度约为90％。结果表明，合成的氘标川芎哚满足药物代谢研究的需要。

Abstract

Deuterated tryptophan was prepared by simple exchange reactions in DC1 orD2O solution. The yield and abundance of deuterated tryptophan obtained from usingDC1 as the deuterium solute was 92% and 98.5% respectively

whereas that by usingD2O was 95% and 96.2% respectively. Deuterated perlolyrine was synthesizedstarting from deuterated tryptophan via acid-catalyzed ring-closure

aromatisationand hydrolysis

with a yield of 11.6% and abundance of about 95%. The labelledperlolyrine was suitable for studying drug metabolism.

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