Effect of Fe<sup>3+</sup> ions on aggregation of glucagon

LIU Jingsong LIU Jianhua ZHANG Yingying WU Zhongliang TAN Juhua LIN Dongdong ZHOU Xingfei

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Effect of Fe³⁺ ions on aggregation of glucagon

更新时间：2021-03-05

- Effect of Fe³⁺ ions on aggregation of glucagon
- NUCLEAR TECHNIQUES Vol. 35, Issue 7, (2012)
- 作者机构：
  
  宁波大学物理系
- 作者简介：
- 基金信息：
- DOI：
  CLC： R312;O572.3
- Published：01 July 2012
- 稿件说明：
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[1]刘京松,刘建华,张莹莹,吴钟良,谭菊花,林冬冬,周星飞.Fe~(3+)离子对胰高血糖素纤维聚集的影响[J].核技术,2012,35(07):552-556.

LIU Jingsong LIU Jianhua ZHANG Yingying WU Zhongliang TAN Juhua LIN Dongdong ZHOU Xingfei. Effect of Fe³⁺ ions on aggregation of glucagon[J]. Nuclear techniques, 2012, 35(7): 552-556.
[1]刘京松,刘建华,张莹莹,吴钟良,谭菊花,林冬冬,周星飞.Fe~(3+)离子对胰高血糖素纤维聚集的影响[J].核技术,2012,35(07):552-556. DOI：

LIU Jingsong LIU Jianhua ZHANG Yingying WU Zhongliang TAN Juhua LIN Dongdong ZHOU Xingfei. Effect of Fe³⁺ ions on aggregation of glucagon[J]. Nuclear techniques, 2012, 35(7): 552-556. DOI：

摘要

研究发现

不少神经类疾病如老年痴呆症和体内淀粉样蛋白的聚集有关

这种蛋白纤维的聚集不仅和氨基酸的序列有关

而且和环境因素如金属离子、pH、温度等密切相关。本文利用原子力显微镜（AFM）观察了加入Fe3+离子后胰高血糖素的聚集过程

并用显微傅立叶变换红外光谱（Micro-FTIR）对聚集成的蛋白纤维的二级结构进行表征。实验结果表明:加入Fe3+离子后

胰高血糖素聚集成纤维的延迟时间大大推迟

同时形成纤维的表面形貌和二级结构都发生了很大变化

而且这种变化和加入的Fe3+离子浓度密切相关。

Abstract

Recent studies show that many neuropathies such as Alzheimer’s disease are associated with the aggregation in vivo of amyloid-like protein.While the aggregation progress depends on sequences of the amino acids

also it is closely related to the environmental factors such as metal ions

temperature etc.In this paper

effect of Fe3+ ions on the aggregation is investigated by atomic force microscopy and micro-FTIR.The results show that the lag time of fibrillation is dramatically extended

and the second structure of formed fibrils changes

too

in glucagon mixed with Fe3+ions.It also suggests that such a change may depend on concentration of added Fe3+ions.

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Related Institution

Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jiading Campus

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Effect of Fe3+ ions on aggregation of glucagon

DOI：

摘要

Abstract

关键词

Keywords

references

Effect of Fe³⁺ ions on aggregation of glucagon