Acupuncture improve motor function in a mouse model of Parkinson’s disease

HUANG Qing SUN Yanhong WANG Lu ZHANG Yi ZHU Ying LI Xiaoming KONG Huating WANG Shaopeng HU Jun FAN Chunhai

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Acupuncture improve motor function in a mouse model of Parkinson’s disease

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- Acupuncture improve motor function in a mouse model of Parkinson’s disease
- NUCLEAR TECHNIQUES Vol. 35, Issue 11, (2012)
- 作者机构：
  
  中国科学院上海应用物理研究所
- 作者简介：
- 基金信息：
  
  国家自然科学基金(批准号:10905086,10975179,10905087,90913014和61008056);上海市自然科学基金(批准号:11ZR1445300);卫生部重大专项(批准号:2009ZX10004-301)资助
- DOI：
  CLC： R245
- Published：01 November 2012
- 稿件说明：
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[1]黄庆,孙艳红,王璐,张一,诸颖,李晓明,孔华庭,王少朋,胡钧,樊春海.针灸对帕金森小鼠模型运动机能调节的分子机制研究[J].核技术,2012,35(11):877-880.

HUANG Qing SUN Yanhong WANG Lu ZHANG Yi ZHU Ying LI Xiaoming KONG Huating WANG Shaopeng HU Jun FAN Chunhai. Acupuncture improve motor function in a mouse model of Parkinson’s disease[J]. Nuclear techniques, 2012, 35(11): 877-880.
[1]黄庆,孙艳红,王璐,张一,诸颖,李晓明,孔华庭,王少朋,胡钧,樊春海.针灸对帕金森小鼠模型运动机能调节的分子机制研究[J].核技术,2012,35(11):877-880. DOI：

HUANG Qing SUN Yanhong WANG Lu ZHANG Yi ZHU Ying LI Xiaoming KONG Huating WANG Shaopeng HU Jun FAN Chunhai. Acupuncture improve motor function in a mouse model of Parkinson’s disease[J]. Nuclear techniques, 2012, 35(11): 877-880. DOI：

摘要

针灸是一种中国传统的医疗手段

它通过将针插入人体特定的部位（穴位）进行刺激从而达到治疗疾病的目的

针灸的疗效已经得到了世界广泛认可。本文重点探讨针灸对帕金森病（Parkinson’s Disease

PD）模型小鼠运动机能的影响及其分子机制

采用1-甲基-4-苯基-1

6-四氢吡啶（MPTP）制备小鼠PD模型

发现针灸阳陵泉穴（GB34）能够保护PD小鼠多巴胺神经元免受损伤

从而改善不协调的运动。对其分子机制的研究还发现了一系列有趣的现象

发现针灸可以促进溶酶体膜的修复和ɑ-synuclein毒性蛋白的降解

提示针灸有可能改善PD小鼠的自噬水平。为揭示针灸治疗的作用机理及分子机制提供了新的思路。

Abstract

Acupuncture is a procedure in which fine needles are inserted into an individual at discrete points and then manipulated

with the intent of treating disease.Acupuncture is practiced worldwide

despite difficulties in reconciling its principles with evidence-based medicine.Here we studied the effect of acupuncture treatment on motor function and its underlying mechanism in mouse model of Parkinson’s Disease（PD） using 1-methyl-4-phenyl-1

6-terahydropyridine（MPTP）.We found that acupuncture treatment at acupoint GB34 improved motor function of model mice.We also found evidence that lysosomal membranes were repaired and ɑ-synuclein was degraded

suggesting that the autophagy level of PD model mice was increased.This study reveals a new possible mechanism of acupuncture treatment.

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Related Author

Chunhai FAN

Jun HU

Lihua WANG

Yanhong SUN

Yi ZHOU

Jiang LI

Chenglie LIN

胡平

Related Institution

Laboratory of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences

School of Basic Medicine, Chengdu University of Traditional Chinese Medicine

Department of Nuclear Medicine, the First Affiliated Hospital of Zhongshan University

中山大学附属第一医院核医学科

State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine

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