Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α<sub>v</sub>β<sub>3</sub>

CHEN Haojun WU Hua

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Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α_vβ₃

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- Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α_vβ₃
- NUCLEAR TECHNIQUES Vol. 35, Issue 9, (2012)
- 作者机构：
  
  厦门大学附属第一医院核医学科
- 作者简介：
- 基金信息：
  
  国家自然科学基金(81101066);福建省科技计划重点项目(2008-59-11);厦门市科技计划指导性项目(3502720077056)资助
- DOI：
  CLC： R817.4
- Published：01 September 2012
- 稿件说明：
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[1]陈皓鋆,吴华.靶向整合素α_vβ_3放射性核素标记分子探针优化策略的研究进展[J].核技术,2012,35(09):715-720.

CHEN Haojun WU Hua. Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α_vβ₃[J]. Nuclear techniques, 2012, 35(9): 715-720.
[1]陈皓鋆,吴华.靶向整合素α_vβ_3放射性核素标记分子探针优化策略的研究进展[J].核技术,2012,35(09):715-720. DOI：

CHEN Haojun WU Hua. Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α_vβ₃[J]. Nuclear techniques, 2012, 35(9): 715-720. DOI：

摘要

恶性肿瘤的持续生长、侵袭、转移依赖于肿瘤血管生成（Angiogenesis）。整合素是细胞表面受体的主要家族

在多种肿瘤细胞表面和新生血管内皮细胞中有较高的表达

是参与调控肿瘤血管增生的重要因子之一

对肿瘤血管生成起着重要作用。含有RGD氨基酸序列（精氨酸-甘氨酸-天冬氨酸序列）的小分子多肽能够与整合素αvβ3特异性结合。因此利用放射性核素标记的RGD多肽在肿瘤的靶向显像和治疗中具有广阔的应用价值。目前RGD多肽分子探针的研究热点集中在探讨RGD探针的优化策略。本文就靶向整合素αvβ3放射性核素标记分子探针优化策略的研究进展作一综述。

Abstract

Tumor angiogenesis is critical in the growth

invasion and metastasis of malignant tumors.The integrins

which express on many types of tumor cells and activated vascular endothelial cells

play an important role in regulation of the tumor angiogenesis.RGD peptide

which contains Arg-Gly-Asp sequence

binds specifically to integrin αvβ3.Therefore

the radiolabeled RGD peptides may have broad application prospects in radionuclide imaging and therapy.Major research interests include the selection of radionuclides

modification and improvement of RGD structures.In this article

we give a review on research progresses in optimization strategy for radiolabeled molecular probes targeting integrin αvβ3.

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ZHANG Chunchun1

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Center of Radiopharmaceuticals,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China) 2

中国科学院研究生院

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Progresses in optimization strategy for radiolabeled molecular probes targeting integrin αvβ3

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摘要

Abstract

关键词

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references

Progresses in optimization strategy for radiolabeled molecular probes targeting integrin α_vβ₃