Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type Ⅱ diabetic patients

WANG Ying JIN Yaoge SHI Xueying GAO Yong

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Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type Ⅱ diabetic patients

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- Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type Ⅱ diabetic patients
- NUCLEAR TECHNIQUES Vol. 34, Issue 10, (2011)
- 作者机构：
  
  上海市徐汇区中心医院核医学科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.2
- Published：01 October 2011
- 稿件说明：
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[1]王瑛,金耀革,施雪莺,高泳.2型糖尿病肾病患者核素肾动态显像和尿微量白蛋白检测的临床意义[J].核技术,2011,34(10):777-780.

WANG Ying JIN Yaoge SHI Xueying GAO Yong. Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type Ⅱ diabetic patients[J]. Nuclear techniques, 2011, 34(10): 777-780.
[1]王瑛,金耀革,施雪莺,高泳.2型糖尿病肾病患者核素肾动态显像和尿微量白蛋白检测的临床意义[J].核技术,2011,34(10):777-780. DOI：

WANG Ying JIN Yaoge SHI Xueying GAO Yong. Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type Ⅱ diabetic patients[J]. Nuclear techniques, 2011, 34(10): 777-780. DOI：

摘要

探讨核素肾动态显像和尿微量白蛋白检测对早期发现糖尿病肾病的临床意义。收集了内科诊断为II型糖尿病为主的住院病人60例

选择临床上无糖尿病和和高血压诊断的对照组20例

两组进行系列常规检查

并做同位素肾图检查来测定肾脏的肾小球滤过率（GFR）

按病人的GFR测定值分为增高（>120 mL/min）、正常（70–120 mL/min）、降低（<70 mL/min）组。这些糖尿病人中高GFR者占8.33%（5/60）

平均为141.98±13.60mg/min

比对照组增高35%

差异非常显著（P<0.01）;GFR正常者占33.33%（20/60）

平均为102.18±10.24mg/min

与对照组相比差异无显著性（P>0.05）;GFR降低者占58.33%（35/60）

平均为57.19±18.00 mg/min

比对照组降低54.3%

差异非常显著（P<0.01）;同时三组病人的尿微量蛋白与对照组相比差异非常显著性（P<0.01）。结果显示

对于糖尿病患者定期联合检测尿微量白蛋白、尿β2-微球蛋白尿和GFR不仅有助于糖尿病肾病的早期诊断

而且还有助于糖尿病肾病的疗效监控和预后判断。

Abstract

To investigate clinical value of glomerular filtration rate(GFR) and urine microalbumin in early diagnosis of diabetic nephropathy

GFR in 60 patients with type Ⅱ diabetes mellitus and a control group of 20 were determined using 99TcmDTPA renal dynamic imaging and urine microalbumin.The following results were obtained.Among the 60 patients with diabetes

5 patients had increased GFRs of

142.0? 13.6mg/min

which was 35% higher than that of controls and differed significantly from the control(P? 0.01);20 patients had GFRs of 102.2? 10.2mg/min

which differed little from the control;and 35 patients had declined GFRs of 57.2±18.0mg/min

which was 54.3% lowered than the control and differed significantly from the control(P<0.01).The urine microalbumin in diabetes patients was significantly higher than the control.In conclusion

the GFR is a good index of the early kidney injury in diabetic patients.The combined detection of GFR and urine microalbumin can improve the early diagnosis of diabetic nephropathy

and may help to monitor the treatment response and assess prognosis.

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