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中国工程物理研究院核物理与化学研究所
Published:01 June 2011
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[1]杨玉青,宋虎,宋宏涛,蒲满飞.含硼卟啉在硼中子捕获治疗中的研究进展[J].核技术,2011,34(06):465-471.
YANG Yuqing SONG Hu SONG Hongtao PU Manfei. Progresses in research of boron porphyrins for boron neutron capture therapy[J]. Nuclear techniques, 2011, 34(6): 465-471.
硼中子捕获治疗(boron neutron capture therapy
BNCT)是利用10B(n
α)7Li反应产生的高能α粒子和反冲7Li原子进行治疗的高传能线密度辐射治疗方式
含硼化合物是硼中子捕获治疗的重要方面
其中含硼卟啉是上世纪90年代起广受关注的含硼化合物。介绍了硼中子捕获治疗及含硼卟啉的特点
阐述了近20年来的研究进展
为设计高效含硼卟啉衍生物提供参考。
Boron neutron capture therapy(BNCT) applies the high linear energy transfer radiation of α particles and 7Li ions released from the 10B(n
α)7Li reaction in pre-localized boron-containing compounds in tumor tissue.Apparently
there are two prime aspects in BNCT
i.e.the outer neutron flux and boron-containing compound.Boron porphyrins is an important 10B-carrier for BNCT under wide research since 1990’s.This paper begins with the characteristics of BNCT
required properties of 10B-carrier and property of porphyrins
then focuses on the application researches of boron porphyrins from main research institutions in the field in the past two decades.This provides a useful reference for further design of better boron porphyrins.
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