Synthesis and radiolabelling of <sup>188</sup>Re labeled dendrimer PAMAM-folic acid conjugate

CUI Wei~

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Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate

更新时间：2021-03-05

- Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate
- NUCLEAR TECHNIQUES Vol. 34, Issue 5, (2011)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所放射性药物中心
  2. 中国科学院研究生院
  3. 上海交通大学系统生物医学研究院系统生物医学教育部重点实验室
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(8107125)资助
- DOI：
  CLC： TQ463
- Published：01 May 2011
- 稿件说明：
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[1]崔巍,张元庆,许晓平,沈玉梅.叶酸修饰PAMAM树状大分子的合成及~(188)Re标记[J].核技术,2011,34(05):386-390.

CUI Wei~. Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate[J]. Nuclear techniques, 2011, 34(5): 386-390.
[1]崔巍,张元庆,许晓平,沈玉梅.叶酸修饰PAMAM树状大分子的合成及~(188)Re标记[J].核技术,2011,34(05):386-390. DOI：

CUI Wei~. Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate[J]. Nuclear techniques, 2011, 34(5): 386-390. DOI：

摘要

叶酸受体在多种肿瘤细胞中过表达是癌症治疗中一种可能的靶向药物结合位点。我们将五代PAMAM树状大分子用叶酸和1B4M-DTPA修饰

然后用

188

Re进行放射性标记。化合物的标记产率为67.5%

分离后的放射化学纯度大于95%

并表现出良好的体外稳定性

为该化合物在叶酸受体靶向肿瘤治疗应用中奠定了基础。

Abstract

Folic acid receptor（FR） was usually overexpressed in many cancer cells and was considered as potential target for targeted therapy agent.We decorated dendrimer polyamidoamine generation five-folic with acid and 1B4M-DTPA and then radiolabeled with

188

Re.Thes in vitro stability was evaluated.The labeling yield of the G5-FA-DTPA-

188

Re was 67.5%

with a radiochemical purity of over 95%.The conjugate also showed high in vitro stability.Further modifications on the dendrimer folic acid conjugate and biological evaluation is in progress and will be reported in due course.

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Related Institution

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) 2

Department of Radiopharmacy, School of Pharmacy, Fudan University

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中国工程物理研究院核物理与化学研究所

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Synthesis and radiolabelling of 188Re labeled dendrimer PAMAM-folic acid conjugate

DOI：

摘要

Abstract

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references

Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate