Comparative PET/CT study with <sup>11</sup>C-MET and <sup>18</sup>F-FDG for diagnosing Glioma

LI Dongli1; 2 XU Yikai2 WANG Quanshi1 WU Hubing1 LI Hongsheng1 1

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Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma

更新时间：2021-03-05

- Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma
- NUCLEAR TECHNIQUES Vol. 34, Issue 2, (2011)
- 作者机构：
  
  1. 南方医科大学南方医院PET中心
  2. 南方医科大学南方医院影像中心
- 作者简介：
- 基金信息：
  
  国家自然科学基金(30370426、30870731)资助
- DOI：
  CLC： R739.4
- Published：01 February 2011
- 稿件说明：
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[1]理东丽,许乙凯,王全师,吴湖炳,李洪生.~(11)C-MET和~(18)F-FDG PET/CT对胶质瘤诊断的价值比较[J].核技术,2011,34(02):151-155.

LI Dongli1, 2 XU Yikai2 WANG Quanshi1 WU Hubing1 LI Hongsheng1 1. Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma[J]. Nuclear techniques, 2011, 34(2): 151-155.
[1]理东丽,许乙凯,王全师,吴湖炳,李洪生.~(11)C-MET和~(18)F-FDG PET/CT对胶质瘤诊断的价值比较[J].核技术,2011,34(02):151-155. DOI：

LI Dongli1, 2 XU Yikai2 WANG Quanshi1 WU Hubing1 LI Hongsheng1 1. Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma[J]. Nuclear techniques, 2011, 34(2): 151-155. DOI：

摘要

对26例胶质瘤和18例颅内良性病变患者行18F-FDG和11C-MET PET/CT颅脑显像

定性和半定量分析两种显像图像。结果显示:11C-MET和18F-FDG PET/CT对胶质瘤诊断的准确率分别为88.6%和65.9%。半定量分析

26例胶质瘤11C-MET摄取值比值T/NGmax显著高于18F-FDG的T/NGmax（1.95±0.52 vs 0.90±0.27

t=9.101

P<0.001）。11C-MET和18F-FDG对高级别胶质瘤诊断的灵敏度无显著差异（100%vs.64.3%;χ2=3.20

P>0.05）;对低级别胶质瘤诊断的灵敏度11C-MET（83.3%）高于18F-FDG（33.3%

χ2=4.16

P<0.05）。11C-MET显像高级别胶质瘤T/NGmax（2.07±0.51）与低级别胶质瘤（1.81±0.52）无显著差异（t=1.302

P=0.205）;18F-FDG显像高级别胶质瘤T/NGmax（1.03±0.30）高于低级别胶质瘤（0.75±0.11

t=3.198

P=0.004）。表明11C-MET PET/CT显像对胶质瘤的诊断

特别是对低级别胶质瘤检出优于18F-FDG

两种显像综合应用有利于胶质瘤的准确分级。

Abstract

In this paper

we investigate the diagnostic value of 11C-methionine(MET) positron emission tomography/computed tomography(PET/CT) for brain gliomas

and compare the results to 18F-fluorodeoxyglucose.Forty-four patients with suspected gliomas were examined with 11C-MET and 18F-FDG PET/CT.18F-FDG and 11C-MET PET/CT images were compared and evaluated by visual and semiquantitative analysis.The accuracy of 11C-MET and 18F-FDG PET/CT for detecting gliomas were 88.6% and 65.9%

respectively.Semiquantitative analysis showed that the 26 gliomas had higher mean ± SD T/NGmax ratio on 11C-MET PET/CT than on 18F-FDG PET/CT(1.95±0.52 vs.0.90±0.27

t=9.101

P<0.001).11C-MET had a higher sensitivity than 18F-FDG(83.3% vs.33.3%

χ2 =4.16

P<0.05) for low-grade gliomas

but it did not differ significantly from 18F-FDG in the sensitivity for high-grade gliomas(100% vs.64.3%

χ2=3.20

P>0.05).The difference was no significant

too

between high-and low-grade gliomas

compared by 11C-MET T/NGmax ratio(2.07±0.51 vs.1.81±0.52

t=1.302

P=0.205).18F-FDG T/NGmax ratio in high-grade gliomas was significantly higher than that in low-grade gliomas(1.03±0.30 vs.0.75±0.11

t=3.198

P=0.004).It is concluded that 11C-MET PET/CT is more accurate than 18F-FDG PET/CT for detecting and delineating gliomas

especially for low-grade gliomas

and it can play a complement role to 18F-FDG in tumor grading.

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WU Hubing

Related Institution

Zibo Wanjie Hospital

Department of PET Center, Nanfang Hospital, Southern Medical University

PET Center, Nanfang Hospital, Southern Medical University

Department of Nuclear Medicine, Shanghai First People’s Hospital, Shanghai JiaoTong University

Department of Nuclear Medicine,The First Affiliated Hospital of Soochow University,Suzhou 215006,China) 2

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Comparative PET/CT study with 11C-MET and 18F-FDG for diagnosing Glioma

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摘要

Abstract

关键词

Keywords

references

Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma