Semi-automated synthesis and preliminary inflammation PET study of(S-[<sup>18</sup>F]-fluoromethyl)-L-cysteine

LIANG Xiang WANG Hongliang TANG Ganghua HUANG Tingting WU Kening

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Semi-automated synthesis and preliminary inflammation PET study of(S-[¹⁸F]-fluoromethyl)-L-cysteine

更新时间：2021-03-05

- Semi-automated synthesis and preliminary inflammation PET study of(S-[¹⁸F]-fluoromethyl)-L-cysteine
- NUCLEAR TECHNIQUES Vol. 34, Issue 12, (2011)
- 作者机构：
  
  中山大学附属第一医院核医学科
- 作者简介：
- 基金信息：
  
  国家高科技计划(863计划)专题课题(2008AA02Z430);国家自然科学基金面上项目(30970856);国际原子能机构(IAEA)资助课题(15245/R0);教育部留学回国启动基金(教外司留[2010]609号)
- DOI：
  CLC： R817.4
- Published：01 December 2011
- 稿件说明：
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[1]梁祥,王红亮,唐刚华,黄婷婷,吴克宁.(S-~(18)F-氟代甲基)-L-半胱氨酸的半自动化合成及其初步炎症PET显像[J].核技术,2011,34(12):937-942.

LIANG Xiang WANG Hongliang TANG Ganghua HUANG Tingting WU Kening. Semi-automated synthesis and preliminary inflammation PET study of(S-[¹⁸F]-fluoromethyl)-L-cysteine[J]. Nuclear techniques, 2011, 34(12): 937-942.
[1]梁祥,王红亮,唐刚华,黄婷婷,吴克宁.(S-~(18)F-氟代甲基)-L-半胱氨酸的半自动化合成及其初步炎症PET显像[J].核技术,2011,34(12):937-942. DOI：

LIANG Xiang WANG Hongliang TANG Ganghua HUANG Tingting WU Kening. Semi-automated synthesis and preliminary inflammation PET study of(S-[¹⁸F]-fluoromethyl)-L-cysteine[J]. Nuclear techniques, 2011, 34(12): 937-942. DOI：

摘要

改进现有合成模块

研究(S-

F-氟代甲基)-L-半胱氨酸(

F-MCYS)的自动化合成工艺

并对无菌炎症模型进行正电子发射断层（PET）显像。以CH

为前体

经氟化反应制备甲基化试剂

F-CH

后者与溶解在二甲基亚砜（DMSO）中的L-半胱氨酸充分反应

用Sep-Pak C18小柱分离纯化

得到

F-MCYS注射液。

F-MCYS的未校正放化产率为（10.0±3.0）%(n=4

按

F计算)

放化纯度

95%

放化合成时间35 min。

F-MCYS可被炎症组织高度摄取

但不稳定

不适于PET显像研究。

Abstract

Semi-automated synthesis of(S-[

F]-fluoromethyl)-L-cysteine(

F-MCYS) was achieved with the modified commercial synthesizer and PET imaging of aseptic inflammatory mice was performed with

F-MCYS.

FCH

Br as

F-fluoromethylation agent was prepared by

F-fluorination of dibromomethane.

F-MCYS was obtained from the reaction of

FCH

Br with L-cysteine dissolved in dimethyl sulfoxide（DMSO） and purification on the solid-phase extraction cartridges.Without correction

the radiochemical yield of

F-MCYS was （10.0±3.0）%(n=4

based on

F )

the radiochemical purity of

F-MCYS was more than 95%

and the total synthesis time was about 35 min.It was found that

F-MCYS had high uptake in the inflammatory tissues

but

F-MCYS was unstable.Thus

F-MCYS is not a potential PET tracer for amino acid imaging and it is necessary for us to develop a novel stable

F-labelled cysteine.

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Related Author

LIANG Xiang WANG Hongliang HUANG Tingting TANG Ganghua HU Kongzhen WU Kening

王红亮

黄婷婷

唐刚华

胡孔珍

吴克宁

WANG Ping ZHANG Guangming LIU Yongchang LIN Xiangtong

张光明

Related Institution

Department of Nuclear Medicine,No.1 Hospital Affiliated to Sun Yat-Sen University

Huashan Hospital,Medical College of Fudan University

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Semi-automated synthesis and preliminary inflammation PET study of(S-[18F]-fluoromethyl)-L-cysteine

DOI：

摘要

Abstract

关键词

Keywords

references

Semi-automated synthesis and preliminary inflammation PET study of(S-[¹⁸F]-fluoromethyl)-L-cysteine