The protective effect of gingerol on anti-oxidative function and hematopoietic system in <sup>60</sup>Coγ-ray irradiated mice

ZHOU Yu XIE Zhenfei GENG Yanyan ZENG Xianyin

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The protective effect of gingerol on anti-oxidative function and hematopoietic system in ⁶⁰Coγ-ray irradiated mice

更新时间：2021-03-05

- The protective effect of gingerol on anti-oxidative function and hematopoietic system in ⁶⁰Coγ-ray irradiated mice
- NUCLEAR TECHNIQUES Vol. 34, Issue 9, (2011)
- 作者机构：
  
  四川农业大学生命理学院原子能农业应用研究室
- 作者简介：
- 基金信息：
  
  教育部“长江学者和创新团队发展计划”创新团队项目(IRT0848);四川农业大学大学生科研兴趣培养计划基金(04050722)资助
- DOI：
  CLC： R285.5
- Published：01 September 2011
- 稿件说明：
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[1]周羽,谢振飞,耿艳艳,曾宪垠.姜辣素对~(60)Coγ辐照损伤小鼠抗氧化功能和造血系统的防护作用[J].核技术,2011,34(09):658-662.

ZHOU Yu XIE Zhenfei GENG Yanyan ZENG Xianyin. The protective effect of gingerol on anti-oxidative function and hematopoietic system in ⁶⁰Coγ-ray irradiated mice[J]. Nuclear techniques, 2011, 34(9): 658-662.
[1]周羽,谢振飞,耿艳艳,曾宪垠.姜辣素对~(60)Coγ辐照损伤小鼠抗氧化功能和造血系统的防护作用[J].核技术,2011,34(09):658-662. DOI：

ZHOU Yu XIE Zhenfei GENG Yanyan ZENG Xianyin. The protective effect of gingerol on anti-oxidative function and hematopoietic system in ⁶⁰Coγ-ray irradiated mice[J]. Nuclear techniques, 2011, 34(9): 658-662. DOI：

摘要

选取24只雌性健康昆明小鼠

随机分成（I）对照组、（II）给药组、（III）照射组、（IV）给药照射组

组II和IV小鼠连续5天灌胃姜辣素

组I和III则灌胃等量的蒸馏水

第六天组III和IV进行5 Gy 60Coγ照射;照后48 h内所有小鼠采血、取骨股、肝脏进行相关指标测定。给药组的骨髓DNA系数、T-SOD（总超氧化物歧化酶）活力、RBC（红细胞）、PLT（血小板）、LYM（淋巴细胞）及WBC（白细胞）均高于对照组

T-AOC（总抗氧化能力）显著上升（p<0.05）;照射组的RBC、LYM、PLT、WBC含量和T-AOC活性显著降低（p<0.05）

T-SOD和骨髓DNA系数极显著降低（p<0.01）;给药照射组RBC、LYM和PLT含量高于照射组

T-AOC显著升高（p<0.05）

T-SOD、WBC和骨髓DNA系数极显著升高（p<0.01）;给药照射组与照射组各指标的比值高于给药组和对照组的比值。结果表明

姜辣素对60Coγ辐照小鼠的抗氧化功能和造血系统具有较强的防护作用。

Abstract

In this work

we investigated the protective effect of gingerol on anti-oxidative function and hematopoietic system of 60Co γ-ray irradiated mice.Twenty-four healthy female Kunming mice were randomly divided into(I) control

(Ⅱ) gingerol

(Ⅲ) irradiation and(IV) gingerol + irradiation groups.Groups Ⅱ and IV were given gingerol intragastrically for five days.Groups Ⅲ and IV were irradiated to 5 Gy by 60Co γ-rays on the 6th day.Blood samples

livers and thigh bones were collected and measured in 48 hours.It was found that the DNA coefficient of bone marrow

T-SOD activities

RBC

PLT

LYM and WBC numbers in Group Ⅱ mice were higher than those in the control group

and T-AOC activities(p<0.05) in the gingerol group increased significantly compared with the control group.The RBC

PLT

LYM and WBC numbers

T-AOC activities(p<0.05)

DNA coefficient of bone marrow and T-SOD activities(p<0.01) in the irradiation group reduced compared with the control group.Compared with irradiation group

T-AOC activities(p<0.05)

T-SOD activities

WBC numbers and DNA coefficient of bone marrow(p<0.01) increased significantly in the gingerol + irradiation group.The ratio of Group IV/Group III is higher than that of Group Ⅱ/Group I.The results demonstrated that gingerol has the protective effect on anti-oxidative function and hematopoietic system of mice irradiated by 60Co γ-rays.

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The protective effect of gingerol on anti-oxidative function and hematopoietic system in 60Coγ-ray irradiated mice

DOI：

摘要

Abstract

关键词

Keywords

references

The protective effect of gingerol on anti-oxidative function and hematopoietic system in ⁶⁰Coγ-ray irradiated mice