Preparation and biodistribution of mixed complexes of <sup>99</sup>Tc<sup>m</sup>-phosphine

ZHANG Huabei  LI Bo  QI Chuanmin  DAI Mei  GUO Xuefeng

doi:null

您当前的位置：

首页 >

文章列表页 >

Preparation and biodistribution of mixed complexes of ⁹⁹Tc^m-phosphine

更新时间：2021-03-12

- Preparation and biodistribution of mixed complexes of ⁹⁹Tc^m-phosphine
- NUCLEAR TECHNIQUES Issue 8, (2003)
- 作者机构：
  
  1. 北京师范大学
  2. 北京师范大学,北京,100875
- 作者简介：
- 基金信息：
  
  国家自然科学青年基金(29801002)资助
- DOI：
  CLC： O641.4
- Published：01 August 2003
- 稿件说明：
移动端阅览
[1]张华北,李波,齐传民,戴梅,郭雪峰.~(99)Tc~m-MVNE-膦混配配合物的制备及其在小鼠体内分布研究[J].核技术,2003(08):613-618.

ZHANG Huabei LI Bo QI Chuanmin DAI Mei GUO Xuefeng. Preparation and biodistribution of mixed complexes of ⁹⁹Tc^m-phosphine[J]. Nuclear techniques, 2003, (8): 613-618.
[1]张华北,李波,齐传民,戴梅,郭雪峰.~(99)Tc~m-MVNE-膦混配配合物的制备及其在小鼠体内分布研究[J].核技术,2003(08):613-618. DOI：

ZHANG Huabei LI Bo QI Chuanmin DAI Mei GUO Xuefeng. Preparation and biodistribution of mixed complexes of ⁹⁹Tc^m-phosphine[J]. Nuclear techniques, 2003, (8): 613-618. DOI：

摘要

为探索锝膦混配配合物的制备方法

寻找新的心肌显像剂

合成了一个新的N3S配体（MVNE）和3个膦配体。通过交换反应在室温下制备了放化纯>95%的99Tcm-MVNE

然后分别与3种膦配体混配得到放化纯>90%的99Tcm-MVNE-膦混配配合物。小鼠体内的生物分布研究表明

该类混配配合物有较高的的心肌摄取

血液清除也较快。

Abstract

To explore the synthetic methods of phosphine mixed complexes of technetium-99m and look for new heart imaging agents

one N3S ligand (MVNE) and three phosphine ligands were synthesized. 99Tcm-MVNE prepared at room temparature through ligand-exchange reaction reacts with the three phosphine ligands respectively to obtain three mixed complexes of 99Tcm-MVNE-phosphine. The biodistribution studies in mice indicate that these complexes exhibit pretty high myocardial uptake and high blood clearance rate.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881077 Visits Today：604

⁰

Preparation and biodistribution of mixed complexes of 99Tcm-phosphine

DOI：

摘要

Abstract

关键词

Keywords

references

Preparation and biodistribution of mixed complexes of ⁹⁹Tc^m-phosphine