Studies of effects of Helicid on glutamate decarboxylase and γ-aminobutyric acid transaminase in mouse brain by using isotope paper chromatography

Xi Zhou; Xilin Cai; Tianrui Zhao; Guohua Nan; Jianyi Li

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Studies of effects of Helicid on glutamate decarboxylase and γ-aminobutyric acid transaminase in mouse brain by using isotope paper chromatography

更新时间：2022-09-13

- Studies of effects of Helicid on glutamate decarboxylase and γ-aminobutyric acid transaminase in mouse brain by using isotope paper chromatography
- Nuclear Techniques Vol. 10, Issue 7, (1987)
- 作者机构：
  
  江西医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：03 February 1986，
  
  Published：1987-07
- 稿件说明：
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Xi Zhou, Xilin Cai, Tianrui Zhao, et al. Studies of effects of Helicid on glutamate decarboxylase and γ-aminobutyric acid transaminase in mouse brain by using isotope paper chromatography[J]. Nuclear techniques, 1987, 10(7): 52-53,F3.
DOI：

Xi Zhou, Xilin Cai, Tianrui Zhao, et al. Studies of effects of Helicid on glutamate decarboxylase and γ-aminobutyric acid transaminase in mouse brain by using isotope paper chromatography[J]. Nuclear techniques, 1987, 10(7): 52-53,F3. DOI：

摘要

豆腐果甙（Helicid，简称Hel）系中国科学院昆明植物研究所从山龙眼科萝卜树（

Helicia erratica Hook

）的果实中提取的一种成分。其化学名为

'-甲酰基苯基-β-D－吡喃阿洛糖甙（4'-formyl-pheny-β-allopyranoside）

[1]

。 Hel有镇静、催眠和一定的抗惊厥作用

[2]

，亦可使氨基硫脲（TSC）降低的小鼠脑中γ－氨基丁酸（GABA）水平恢复正常

[3]

。为此，我们用放射性酶测定法观察了Hel对小鼠脑谷氨酸脱羧酶（GAD）和GABA转氨酶（GABA-T）活性的影响。

Abstract

Effects of Helicid (Hel) on glutamate decarbcxylase (GAD) and γ-aminobutyric acid transaminase (GABA-T) in the brain of normal and convulsive mice elicited by thiose-micarbazide (TSC) were studied by isotope paper chromatography. It showed that there was no obvious effect of Hel on GAD of normal or on GABA-T of normal and convulsive mice

but Hel could recover the GAD activity inhibited by TSC

which may be relative to its strengthening of inhibition of central nervous system

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references

Chen Wei-shi et al . , Liebigs. Ann. Chem. , 1893 （ 1981 ）.

王懋德，中国药理通讯， 3—4 , 194 （ 1984 ）。

周曦等，豆腐果甙对小鼠脑及突触中某些氨基酸代谢的影响，中国药理学报（待发表）。

R. Fried ed. , Methods of neurochemistry , Vol. 3 , Marcel Dekker INC. New York , 1972 , p. 1 .

温博贵，生理科学进展， 11 ， 26 （ 1980 ）。

J. D. Wood et al . , J. Neurochem . , 18 , 1017 （ 1971 ）.

I. Kanazawa et al . , ibid . , 27 , 1267 （ 1976 ）.

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