Labelling of Tc-99m-hexakis (t-butylisonitrile) (TBI) and its distribution in animals

Yuzhi Guo; Qinfang Kuang; Bin Low; Ping Fang; Yian Zhao

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Labelling of Tc-99m-hexakis (t-butylisonitrile) (TBI) and its distribution in animals

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- Labelling of Tc-99m-hexakis (t-butylisonitrile) (TBI) and its distribution in animals
- Nuclear Techniques Vol. 09, Issue 11, (1986)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：03 February 1986，
  
  Published：1986-11
- 稿件说明：
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Yuzhi Guo, Qinfang Kuang, Bin Low, et al. Labelling of Tc-99m-hexakis (t-butylisonitrile) (TBI) and its distribution in animals[J]. Nuclear techniques, 1986, 09(11): 51-53,63.
DOI：

Yuzhi Guo, Qinfang Kuang, Bin Low, et al. Labelling of Tc-99m-hexakis (t-butylisonitrile) (TBI) and its distribution in animals[J]. Nuclear techniques, 1986, 09(11): 51-53,63. DOI：

摘要

本文报道使用均相配体交换法标记

99m

锝-特丁基异腈（

99m

Tc-TBI）的方法和步骤。该法标记方便，产额和放射化学纯度均大于90%，便于临床推广和使用。

99m

Tc-TBI在大鼠血中清除较快，T

1/2

α为3.7min，

1/2

为63min，给药后1和2h的心／血比分别为62.2和48.7，心／肺比为3.7和4.0，心／肝比为0.85和0.81，给药后1、2和4h时每克小鼠心肌的百分吸收值分别为11.1±2.6%13.1±2.1%和12.8±1.5%。可见，

99m

Tc-TBI是一种新型的、有希望的心肌显象剂。

Abstract

This paper reports the labelling method and procedure of Tc-99m-TBI preparation by homogeneous ligand exchanging

This labelled method is easy

with the labelling. rate and radiochemistry purity over 90%. It is convenient to use and popularize in clinic. The clearance of Tc-99m-TBI from the blood in rats was quick

1/2

was 3.7 min

1/2

β was 63 min. Heart/blood ratio was 62.2 and 48.7 in mice at 1 and 2h after giving drug

while heart/liver ratio was 0.85 and 0.81

and heart/lung ratio was 3.7 and 4.0. And dose %/g organ was 11.1±2.6%

13.1±2.1% and 12.8±1.5% in myocardium of mice at 1

4h after injection. The Tc-99m-TBI was a new promising myocardial imaging agent.

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Keywords

references

D. B. Pendleten , et al . , J. Nucl. Med. , 25 , 24 （ 1984 ）（abstr）

B. Leanard Holman et al . , J. Nucl. Med. , 25 , 1350 （ 1984 ）.

吉连成等，中华核医学杂志 , 3 , 158 （ 1983 ）.

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Related Author

Fenzhi Lin

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Shanghai Institute of Nuclear Research, Academia Sinicu

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