The measurement of C-13-methacetin in serum by isotope reverse dilution analysis method

Yaer Hu; Tengchang Dai; Zongqin Xia

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The measurement of C-13-methacetin in serum by isotope reverse dilution analysis method

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- The measurement of C-13-methacetin in serum by isotope reverse dilution analysis method
- Nuclear Techniques Vol. 09, Issue 7, (1986)
- 作者机构：
  
  上海第二医科大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：14 June 1985，
  
  Published：1986-07
- 稿件说明：
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Yaer Hu, Tengchang Dai, Zongqin Xia. The measurement of C-13-methacetin in serum by isotope reverse dilution analysis method[J]. Nuclear techniques, 1986, 09(7): 56-58,42,63,64.
DOI：

Yaer Hu, Tengchang Dai, Zongqin Xia. The measurement of C-13-methacetin in serum by isotope reverse dilution analysis method[J]. Nuclear techniques, 1986, 09(7): 56-58,42,63,64. DOI：

摘要

我们过去的工作表明，口服

C-美沙西汀后，呼出气中

СО

的排出因肝功能障碍而延迟。这种延迟有两个可能的原因，一是肝细胞氧化美沙西汀的能力降低，二是肝功能障碍导致的肠吸收美沙西汀变慢。为此，用GC-MS技术以同位素反稀释法测定了口服

C-美沙西汀15分钟后，血清中该标记物的浓度。测定结果。肝硬化患者血清

C-美沙西汀含量显著高于正常人。证明肠吸收不良对

C-美沙西汀呼气试验的结果无明显干扰，

的排出延缓主要反映肝功能障碍。此外，血清含量的测定本身也有反映肝功能障碍的作用。

Abstract

In this work

C-13-methacetin contents in serum were measured in several normal adults and hepatic patients by isotope reverse dilution analysis using GC-MS technique.

The result showed that the serum C-13-methacetin content of hepatic cirrhosis patients (1.050±SEM 0.227 µg/ml) was singnificantly higher than normal (0.209 ± SEM 0.038µg/ml). Therefore it is clear that the delay of

elimination in hepatic patients is mainly caused by the malfunction of liver in oxidizing mathacetin

and the influence of absorption rate is negligible.

关键词

Keywords

references

T. A. Baillie ed. , Stable isotopes , MacMillan Press , London , 1978 , p. 3 .

ibid , p. 27 .

戴腾昌等，稳定同位素， 3 ， 1 （ 1983 ）。

邱以永等，中华核医学杂志， 4 ， 3 , 129 （ 1984 ）。

夏宗勤等，核技术， 3 ， 1 （ 1985 ）。

胡雅儿等，稳定同位素， 3 ， 20 （ 1983 ）。

J. D. Baty et al . , Biomedical mass spect. , 3 , 60 （ 1976 ）.

胡雅儿等，稳定同位素， 4 ， 17 （ 1983 ）。

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