A rapid labelling method for <sup>125</sup>I-META-iodobenzylguanidine (<sup>125</sup>I-M-IBG)

Changzheng Liu; Rui Shi; Lei Shi; Zheng Fang; Rongchang Chen; Jinghua Wu; Guanxiang Huang

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A rapid labelling method for ¹²⁵I-META-iodobenzylguanidine (¹²⁵I-M-IBG)

更新时间：2022-09-13

- A rapid labelling method for ¹²⁵I-META-iodobenzylguanidine (¹²⁵I-M-IBG)
- Nuclear Techniques Vol. 09, Issue 5, (1986)
- 作者机构：
  
  1.中山医学院
  2.广州军区总医院
  3.广东省药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：28 March 1984，
  
  Published：1986-05
- 稿件说明：
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Changzheng Liu, Rui Shi, Lei Shi, et al. A rapid labelling method for ¹²⁵I-META-iodobenzylguanidine (¹²⁵I-M-IBG)[J]. Nuclear techniques, 1986, 09(5): 47-49,62.
DOI：

Changzheng Liu, Rui Shi, Lei Shi, et al. A rapid labelling method for ¹²⁵I-META-iodobenzylguanidine (¹²⁵I-M-IBG)[J]. Nuclear techniques, 1986, 09(5): 47-49,62. DOI：

摘要

本文介绍了用碘代芳烷基溴与游离胍缩合，合成了肾上腺髓质显像剂——间位碘代苄胍硫酸盐（MIBG sulfate）；同时介绍了放射性碘标记MIBG的快速标记方法——热液熔融法；探讨了标记的最佳条件，确定标记反应温度为170—180℃、反应时间为1h、溶液体积为20—25µl，标记率可达95%。

Abstract

Experimental result of a rapid labelling method

namely

the hydrothermal melting method is described. Our results indicate clearly that the hydrothermal melting method

which is simple

easy and rapid

obviously excels the heat refluxed method. The best reaction temperature is 180℃; reaction time

60 min.; reaction solution volume

20µl; and labelling efficiency

above 95%. The mechanism of isotopic exchange reaction is also studied.

关键词

Keywords

references

L. S. Goodman and A. Gilman eds. , Pharmacological basis of therapeutics , 5th ed , New York , Macmillan Publishing Co. , 1975 , p . 553 .

D. M. Wieland et al . , J. Nucl. Med. , 21 , 349 ( 1980 ).

D. M. Wieland et al . , ibid , 22 , 358 ( 1981 ).

翁皓珉等，核化学与放射化学， 5 , 154 ( 1983 ).

A. H. 穆林等（陶祖贻等译），放射化学与核过程化学（第一册）， 1965 年， 181 页。

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A rapid labelling method for 125I-META-iodobenzylguanidine (125I-M-IBG)

DOI：

摘要

Abstract

关键词

Keywords

references

A rapid labelling method for ¹²⁵I-META-iodobenzylguanidine (¹²⁵I-M-IBG)