Distribution and whole-body autoradiography of <sup>3</sup>H-dimethy- (-) -curine dimethochloride in pregnant rats

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Distribution and whole-body autoradiography of ³H-dimethy- (-) -curine dimethochloride in pregnant rats

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- Distribution and whole-body autoradiography of ³H-dimethy- (-) -curine dimethochloride in pregnant rats
- Nuclear Techniques Vol. 08, Issue 5, (1985)
- 作者机构：
  
  上海医药工业研究院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1985
- 稿件说明：
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Shuixing Li, Jianqing Jiang, Ruyue Gao, et al. Distribution and whole-body autoradiography of ³H-dimethy- (-) -curine dimethochloride in pregnant rats[J]. Nuclear techniques, 1985, 08(5): 62-62,61.
DOI：

Shuixing Li, Jianqing Jiang, Ruyue Gao, et al. Distribution and whole-body autoradiography of ³H-dimethy- (-) -curine dimethochloride in pregnant rats[J]. Nuclear techniques, 1985, 08(5): 62-62,61. DOI：

海轮碱Ⅰ是一个较为理想的新的肌松剂。在前文

[1]

基础上，本文用整体放射自显影技术对本品在怀孕大鼠体内的分布进行了研究。

1．方法　［

H］海轮碱Ⅰ系中科院上海原子核所制备，放射性比活度为6Ci/mmol，放化纯度＞90%。该药是2%乙醇水溶液，以生理盐水稀释后供静脉注射。取妊娠十八天的大鼠3只，尾静脉注射［

H］海轮碱Ⅰ1mCi/kg（137

g/kg），分别于给药后2分、4小时及24小时将动物投入己烷－干冰（-78℃）溶液中速冻处死，5%

CMC

包埋固定后，作冷冻切片。切片厚度为30

m，粘贴于Scotch胶带上。切片经冷冻（-20℃）干燥后，置曝盒中接触法在室温下曝光90天。然后取出胶片进行显影、定影、水洗及晾干。

李水兴等，核技术， 2 ， 52 （ 1984 ）。

E. N. Cohen et al ., Anesthesiology , 29 , 5 , 987 （ 1968 ）.

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Distribution and whole-body autoradiography of 3H-dimethy- (-) -curine dimethochloride in pregnant rats