Preparation of DL-[4-<sup>3</sup>H]-phenylalanine

Dawei You; Guoping Fan

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Preparation of DL-[4-³H]-phenylalanine

更新时间：2022-09-13

- Preparation of DL-[4-³H]-phenylalanine
- Nuclear Techniques Vol. 08, Issue 5, (1985)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：22 January 1984，
  
  Published：1985
- 稿件说明：
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Dawei You, Guoping Fan. Preparation of DL-[4-³H]-phenylalanine[J]. Nuclear techniques, 1985, 08(5): 28-29,58.
DOI：

Dawei You, Guoping Fan. Preparation of DL-[4-³H]-phenylalanine[J]. Nuclear techniques, 1985, 08(5): 28-29,58. DOI：

摘要

DL-

［

H］-苯丙氨酸是生物化学、遗传工程等广为使用的氚标记化合物之一。以前大都采用N-乙酰胺基肉桂酸的催化氚化来制备

[1~3]

。此方法工艺流程长、操作复杂。为此，我们采用了催化卤－氚交换法来制备DL-［4-

H］-苯丙氨酸，并获得了成功。比放射性为16.6Ci/mmol，产品经三种溶剂系统纸层析和放射性扫描测定放化纯度均在95%以上。

Abstract

DL-[4-

H]-phenylalanine was prepared by catalytic halogen-tritium exchange method The labelled T was removed by repeated equilibration with methanol and water. Finally the product was purified by paper chromatograph. The specific radioactivity of DL-[4-

H]-phenylalanine is 16.6 Ci/mmol. The radiochemical purity is more than 95%.

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references

Ch. Gerday and W. G. Verly , J. Label, comp ., 4 , 4 , 334 （ 1968 ）.

范国平等，标记化合物，原子能出版社， 1979 年，第 63 页。

E. Evans , Tritium and its compounds , second Edition , 1974 , p. 318 .

中国科学院上海生物化学研究所，生物化学与生物物理进展， 3 . 19 （ 1976 ）。

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Preparation of DL-[4-3H]-phenylalanine

DOI：

摘要

Abstract

关键词

Keywords

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Preparation of DL-[4-³H]-phenylalanine