Synthesis of carbon-14 labelled alloxan

Yiefang Ye; Zentang Zhou; Dequn Shen; Yun Wang

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Synthesis of carbon-14 labelled alloxan

更新时间：2022-09-13

- Synthesis of carbon-14 labelled alloxan
- Nuclear Techniques Vol. 07, Issue 6, (1984)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：20 September 1983，
  
  Published：1984-06
- 稿件说明：
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Yiefang Ye, Zentang Zhou, Dequn Shen, et al. Synthesis of carbon-14 labelled alloxan[J]. Nuclear techniques, 1984, 07(6): 59-59,56,69.
DOI：

Yiefang Ye, Zentang Zhou, Dequn Shen, et al. Synthesis of carbon-14 labelled alloxan[J]. Nuclear techniques, 1984, 07(6): 59-59,56,69. DOI：

摘要

四氧嘧啶能破坏胰岛细胞而引起糖尿病。医学上用它使动物致糖尿病，作为病理研究的模型；我们以

C标记它，供动物体内分布试验和基础医学研究使用。

1952年M. L. Tamayo等人首先合成2-

C-四氧嘧啶

[1]

：是以

C-脲素与丙二酸二乙酯缩合制得[2-

C]-巴比妥酸，再与苯甲醛反应生成5-苄叉巴比妥酸，然后用氧化铬氧化成四氧嘧啶。其化学反应式如下：

Abstract

This paper describes synthesis of 2-

C-Alloxan from

C-urea condensation with malonic ester to form barbituric acid

and directly oxidization of it by chromium oxide. The yield of two steps was 50%. The chemical and radiochemical purities of Alloxan assessed by paper chromatography were over than 95%. The specific activity of barbituric acid was 2.84 mCi/mmol and that of Alloxan was 2.46 mCi/mmol.

关键词

Keywords

references

M. L. Tomayo et al ., Chem. Abstr. 48 , 1278d ( 1952 ).

F. Pochon et al ., ibid , 55 , 25967h ( 1961 ).

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