The preparation of <sup>99m</sup>Tc-labelled urokinase as a thromboemboli imaging agent and its animals tests

Ruiying Fang; Huiyang Zhao; Wenguan Liu; Feng Qian; Kejing Chen; Youxian Feng; Guohua Yang; Jiajin Zheng; Meiying Fan; Bohui Wu; Mingxuan Li; Yisi Chen

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The preparation of ^99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests

更新时间：2022-09-13

- The preparation of ^99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests
- Nuclear Techniques Vol. 07, Issue 6, (1984)
- 作者机构：
  
  上海第一医学院附属中山医院
  2.上海试剂研究所
  3.上海生物制药厂
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：04 November 1983，
  
  Published：1984-06
- 稿件说明：
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Ruiying Fang, Huiyang Zhao, Wenguan Liu, et al. The preparation of ^99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests[J]. Nuclear techniques, 1984, 07(6): 43-46,67.
DOI：

Ruiying Fang, Huiyang Zhao, Wenguan Liu, et al. The preparation of ^99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests[J]. Nuclear techniques, 1984, 07(6): 43-46,67. DOI：

摘要

尿激酶（

Urokinase

）为自人尿中提取的高纯度的乾冻酶制剂。尿激酶能直接激活体内纤溶酶元，转变为纤溶酶。纤溶酶具有强烈的水解纤维蛋白的作用，从而达到溶解血栓的效果。用

99m

Tc标记尿激酶后，仍然保持一定的生物活力，将标记物注入到人体后，通过

照相或闪烁扫描进行显像可以寻找血栓位置。

Abstract

This paper describes the preparation and animal tests of

99m

Tc-labelled urokinase thromboemboli imaging agent. This agent can be localized in thrombus after injection and visualized by Gamma camera or scintillation scanner. There is no allergic reaction from non antigen reaction.

99m

Tc-urokinase can be used not only in diagnosis of deep vein thrombosis

but also in locating thrombus in transplant organs.

关键词

Keywords

references

R. Paoletti and S Sherry , Thrombosis and urokinase (proccings of the terono symposia) , Vol. 9 , 1977 , P. 17 .

W. T. Millar et al ., Localization of deep-venous thrombosis using technetium-99m-labeling urokinase Lancet 2 : 695—696 , 1974 .

R. R. Bertil , J. Nucl. Med ., 16 , 474 ( 1975 ).

K. O. Dugarm , et al ., J. Nucl. Med ., 14 , 233 , ( 1973 ).

M. M. Penny et al ., Brit. J. Radiol ., 50 , 518 , ( 1977 ).

S. L. Sylvia and J. Harwig , J. Nucl. Med ., 17 , 40 , ( 1976 ).

上海市医学化验所主编，临床生化检验上册，上海科技出版社， 1979年。

F. Viaras et al ., J. Nucl. Med ., 21 , 723 ( 1980 ).

A. Philip , J. Nucl. Med ., 22 , 598 , ( 1981 ).

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金坚

Related Institution

State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine

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南京市医学放射免疫检测中心南京市第一医院

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The preparation of 99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests

DOI：

摘要

Abstract

关键词

Keywords

references

The preparation of ^99mTc-labelled urokinase as a thromboemboli imaging agent and its animals tests