Transport of radiothallium through cell membrane of human erythrocyte

Xichang Shi; Yongchuan Wang; Qianmei Ji; Defeng Xie; Qixun Sun

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Transport of radiothallium through cell membrane of human erythrocyte

更新时间：2022-09-13

- Transport of radiothallium through cell membrane of human erythrocyte
- Nuclear Techniques Vol. 06, Issue 2, (1983)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：21 January 1982，
  
  Published：1983-04
- 稿件说明：
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Xichang Shi, Yongchuan Wang, Qianmei Ji, et al. Transport of radiothallium through cell membrane of human erythrocyte[J]. Nuclear techniques, 1983, 06(2): 56-57,79.
DOI：

Xichang Shi, Yongchuan Wang, Qianmei Ji, et al. Transport of radiothallium through cell membrane of human erythrocyte[J]. Nuclear techniques, 1983, 06(2): 56-57,79. DOI：

摘要

放射性铊（T1）药物对心肌和肿瘤组织具有一定的亲和性，1974年

201

[1]

用于临床后，核医学领域用它作为心脏疾患诊断显影剂已为很多人熟悉，不仅如此，也有人用它作为某些肿瘤的定位显影剂。本文主要介绍

201

T1在人红细胞膜中（包括在Na

＋

，K

＋

-ATP酶的特异性抑制剂毒毛旋花苷的存在下）转运观察，探索

201

T1在细胞膜中的转运机理。为了证明

20t

T1在人红细胞膜中转运观察方法的可靠性，我们还做了

Rb在红细胞膜中的转运观察。

Abstract

The time course of radio thallium-201

200

200 monochloride (Tl) uptake by washed human erythrocytes was studied in vitro. There was an initial rapid influx of Tl

which decreased with the time. The uptake of Tl is inhibited by ouabain and enhanced with the increase of concentration (10

-9

~10

-5

). The uptake of Tl was greatly reduced with the presence of potassium in the suspending media. Our results indicate that transport of Tl through cell membrance of human erythrocyte may be related to Na

-ATP dse.

关键词

Keywords

references

Danish Patent , 67277 , ( 1943 ).

U. S. Patent , 2442863 , ( 1944 ).

Bjrnholm et al . , Nucl. Instr, Meth ., 5 , 196 ( 1959 ).

V. Verdingh and K. F. Lawer , Nucl. Instr. Meth ., 60 , 125 ( 1968 ).

G. P. Gutierrez et al . , J. Electrochem. Soc ., 109 ( 1962 ).

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