Encapsulation of antitumor drug methotrexate in liposome vesicles

Bo Xu; Qixun Sun; Nianbao Zhang; Binghua Xie; Jiong Zhang

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Encapsulation of antitumor drug methotrexate in liposome vesicles

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- Encapsulation of antitumor drug methotrexate in liposome vesicles
- Nuclear Techniques Vol. 13, Issue 5, (1990)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：30 November 1988，
  
  Published：1990-05
- 稿件说明：
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Bo Xu, Qixun Sun, Nianbao Zhang, et al. Encapsulation of antitumor drug methotrexate in liposome vesicles[J]. Nuclear techniques, 1990, 13(5): 317-320.
DOI：

Bo Xu, Qixun Sun, Nianbao Zhang, et al. Encapsulation of antitumor drug methotrexate in liposome vesicles[J]. Nuclear techniques, 1990, 13(5): 317-320. DOI：

摘要

研制了包裹抗癌药氨甲喋呤（MTX）的脂质体。MTX用氚离子束标记法进行氚标记，经薄层层析制备得到纯的

H-MTX，比活性为1.19GBq/mmol，放化纯度

95%。以

H-MTX为示踪剂研究脂质体在各种制备条件下对MTX的包裹率，其值可达21—53%。

Abstract

Liposome vesicles containing antitumor drug methotrexate (MTX) were prepared. MTX was labelled by the tritium ion beam method. After purification by TLC

the specific radioactivity of

H-MTX was 1.19GBq/mmol with radiochemical purity over 95%. Under various forming conditions of liposome vesicles

the efficiency of encapsulation was 21-53%.

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references

V. J. Caride et al ., J. Nucl. Med. , 17 ( 1976 ), 1067 .

D. Papahadjopoulos et al ., U.S. patent, 4235871 , 25, Nov. 1980 .

D. Papahadjopoulos et al ., Proc. Nati., Acad. Sci., USA , 75 ( 1978 ), 9 : 4194 .

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