Selection of methods for determining radiochemical purity of (<sup>201</sup>Tl) thallous chloride

Tiansen Huans; Hongzhu Jiang; Wei Yan; Changyu Xu

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Selection of methods for determining radiochemical purity of (²⁰¹Tl) thallous chloride

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- Selection of methods for determining radiochemical purity of (²⁰¹Tl) thallous chloride
- Nuclear Techniques Vol. 13, Issue 3, (1990)
- 作者机构：
  
  上海市药品检验所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：06 February 1988，
  
  Published：01 March 1990
- 稿件说明：
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Tiansen Huans, Hongzhu Jiang, Wei Yan, et al. Selection of methods for determining radiochemical purity of (²⁰¹Tl) thallous chloride[J]. Nuclear techniques, 1990, 13(3): 172-175.
DOI：

Tiansen Huans, Hongzhu Jiang, Wei Yan, et al. Selection of methods for determining radiochemical purity of (²⁰¹Tl) thallous chloride[J]. Nuclear techniques, 1990, 13(3): 172-175. DOI：

摘要

本文以同一批氯化亚铊和氯化铊为供试品，采用醋酸纤维薄膜电泳、纸电泳、预饱和纸层析及非饱和纸层析等不同方法进行比较，发现上述方法均能将供试品中的铊

201

Tl（I）和铊

201

T1（I）分离。以氯化亚铊（

201

Tl）作供试品时，测得

201

Tl（I）数值接近；以氯化铊（

201

Tl）作供试品时，四种方法测定的

201

Tl（Ⅱ）的结果很不一致。采用Na

HPO

：丙铜=10:90为展开剂，预饱和上行纸层析的方法，能有效地测出供试品中

201

Tl（Ⅱ），误差小，重复性好。为此，推荐上述方法为氯化亚铊（

201

Tl）放射化学纯度测定方法

Abstract

Different kinds of chromatographic and electrophoretic methods for determining(

201

Tl) thallous chloride and thallic chloride were compared in same batch of sample. It was found that mono-valent and tri-valent

201

Tl ions could be separated by using cellulose acetate-electrophoresis

paper electrophoresis

pre-saturation paper chromatography and non-saturation paper chromatography. Very close results for the amount of mono-valent

201

Tl were obtained when (

201

Tl) thallous chloride samples were used for the determination. However

it was not consistent for tri-valent

201

Tl using the four methods described above. The amount of tri-valent

201

Tl was determined effectively by the ascending presaturation paper chromatography method using Na

HPO

-acetone (10:90) as developing agent. The method

with the advantages of good reproducibility and small error

is there fore recommended for the determination of radiochemical purity of (

201

Tl) thallous chloride.

关键词

Keywords

references

Lebowitze et al . , J. Nucl. Med. , 16 （ 1975 ）, 151 .

Thallous Chloride 201 Tl Injection: The United States Pharmacopeia, XXI , ( 1986 ).

盐化夕ソウワ（ 201 Tl）注射液，日本药局方第十一改正， 1986 年．

A. C. James et al . , J. Lab. Com. Radio.Pharmac. , ?? （ 1977 ）, 3 : 437 .

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Related Institution

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中国科学院上海原子核研究所

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Selection of methods for determining radiochemical purity of (201Tl) thallous chloride

DOI：

摘要

Abstract

关键词

Keywords

references

Selection of methods for determining radiochemical purity of (²⁰¹Tl) thallous chloride