Myocardial imaging agent synthesis of Tc-99m-p-TPA-DTS and its primary animal experiment

Liren Shao; Xirui Zhou; Guohui Chen; Weiliang Wu; Gang Huang; Huiyang Zhao; Ainuo Yuan

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Myocardial imaging agent synthesis of Tc-99m-p-TPA-DTS and its primary animal experiment

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- Myocardial imaging agent synthesis of Tc-99m-p-TPA-DTS and its primary animal experiment
- Nuclear Techniques Vol. 13, Issue 2, (1990)
- 作者机构：
  
  1.上海医科大学药学院
  2.上海医科大学中山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：25 January 1988，
  
  Published：01 February 1990
- 稿件说明：
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Liren Shao, Xirui Zhou, Guohui Chen, et al. Myocardial imaging agent synthesis of Tc-99m-p-TPA-DTS and its primary animal experiment[J]. Nuclear techniques, 1990, 13(2): 124-128.
DOI：

Liren Shao, Xirui Zhou, Guohui Chen, et al. Myocardial imaging agent synthesis of Tc-99m-p-TPA-DTS and its primary animal experiment[J]. Nuclear techniques, 1990, 13(2): 124-128. DOI：

摘要

3-（对三甲氨乙基）-苯丙烷－2

3－二酮－双（N－甲基缩氨基硫脲）-碘化物（p-TPA-DTS）是由氨乙基苯为原料，通过甲基化、丙酰化、亚硝基化和与甲缩氨基硫脲缩合及季铵化合成的。该化合物在pH3的水溶液中，由氯化亚锡还原高锝酸钠制备而得锝－99m－胺苯缩硫脲，本品用兔实验显示清晰的心肌显像，并能迅速经肝脏细胞运行。

Abstract

3-(p-Trimethylaminoethyl)-phenylpropane - 2

3-dione-bis-(N-methyl - thiosemicarba-zone)-iodide (p-TPA-DTS) was synthesized by methylation of aminoethylbenzene

followed by propionylation

nitrosation

reaction with methylth iosemicarbazide and quarternization. Tc-99m-complex of this compound was prepared by stannous chloride reduction of sodium pertechnetate in aqueous at pH 3. Tc-99m-p-TPA-DTS possessed a clear myocardial image and rapid hepatocellular transit in rabbits.

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references

J. Hosotani et al . , J. Label. Compounds Radiopharm. , 21 （ 1984 ）, 1067 .

E. Deutsch et al . , J. Nucl. Med. , 22 （ 1981 ）, 897 .

赵惠扬等，核技术， 10 （ 1987 ）， 6 : 50 。

Yokoyama and Akira , JP 59/046264 A2（CA. 101, 35249n） .

Smolik and Stanislav , CZEC, 138018（CA. 75, 140302y ）.

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