Synthesis and animal studies of technetium-99m MAG<sub>3</sub>, a renal function imaging agent

Weizhen Gao; Fang Chen; Yuping Li; Shizhen Wang; Liyi Lu

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Synthesis and animal studies of technetium-99m MAG₃, a renal function imaging agent

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- Synthesis and animal studies of technetium-99m MAG₃, a renal function imaging agent
- Nuclear Techniques Vol. 13, Issue 1, (1990)
- 作者机构：
  
  1.北京协和医院
  2.北京师范大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：22 February 1988，
  
  Published：01 January 1990
- 稿件说明：
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Weizhen Gao, Fang Chen, Yuping Li, et al. Synthesis and animal studies of technetium-99m MAG₃, a renal function imaging agent[J]. Nuclear techniques, 1990, 13(1): 57-60.
DOI：

Weizhen Gao, Fang Chen, Yuping Li, et al. Synthesis and animal studies of technetium-99m MAG₃, a renal function imaging agent[J]. Nuclear techniques, 1990, 13(1): 57-60. DOI：

摘要

由三甘氨肽与氯乙酰氯、苯甲硫羟酸反应得到

99m

Tc-MAG

的前体化合物B

-MAG

，并用

99m

Tc标记，即得

99m

Tc-MAG

，标记率达97%。经动物实验表明：

99m

Tc-MAG

能以原形快速经肾排泄。

Abstract

A technetium-chelating agent

mercaptoacetylglycylglycylglycine (MAG

)

was synthesized and chelated with

99m

Tc. Animal studies of

99m

Tc-MAG

indicated that it excretes faster than o-iodohippurate (OIH) both in normal and in probenecid treated animals.

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references

Alan R. Fritzberg et al . , J. Nucl. Med. , 27 ( 1986 ), 111 .

Paul Noble et al . , Org. Synth. Coll. Vol. 4 : 924 .

Alan R. Fritzberg , Eur. Pat. Appl. , Ep173, 424 (c1. A61K 49/02) , 05 Mar 1986 ,

US Appl. 624, 098 , 25 Jun.1984 ; 53pp .

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Synthesis and animal studies of technetium-99m MAG3, a renal function imaging agent

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis and animal studies of technetium-99m MAG₃, a renal function imaging agent