Preparation of N-succ nimidyl (2, 3-<sup>3</sup>H) propionate

Zuoen Zhang; Zhimin Li; Xiongqi Gong

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Preparation of N-succ nimidyl (2, 3-³H) propionate

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- Preparation of N-succ nimidyl (2, 3-³H) propionate
- Nuclear Techniques Vol. 12, Issue 12, (1989)
- 作者机构：
  
  军事医学科学院毒物药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：04 November 1987，
  
  Published：1989-12
- 稿件说明：
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Zuoen Zhang, Zhimin Li, Xiongqi Gong. Preparation of N-succ nimidyl (2, 3-³H) propionate[J]. Nuclear techniques, 1989, 12(12): 747-749.
DOI：

Zuoen Zhang, Zhimin Li, Xiongqi Gong. Preparation of N-succ nimidyl (2, 3-³H) propionate[J]. Nuclear techniques, 1989, 12(12): 747-749. DOI：

摘要

H-NSP是目前将氚引入到蛋白质和多肽的一种重要试剂。其前体N-琥珀酰亚胺丙烯酸酯是用丙烯酸和N-羟基琥珀酰亚胺在二环己基碳二亚胺存在下缩合得到。然后再以10%钯碳催化氚化制得。粗品通过硅胶层析纯化放化纯~95%，比度1.35TBq/mmol。

Abstract

H-NSP is current important reagent for introduction of tritium into proteins and polypeptide. The precursor

N-succinimidyl acrylate was obtained by the reaction of acrylic acid with N-hydroxysuccinimide in the presence of DCC and it was tritiated with tritium gas in the presence if 10% Pd-C catalyst. The crude product was purified by silica gel chromatography. The radiochemical purity and specific activity were ~95%and 1.35 TBq/mmol respectively.

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references

王家蓓和孙曼霁，中国药理学与毒理学杂志，（ 1986 ）， 1 ： 20 .

张翰和孙曼霁，毒物药物研究所工作报告， 1986 年。

李风珍和孙曼霁，毒物药物研究所工作报告， 1986 年。

刘昌玲，毒物药物研究所工作报告， 1986 年。

J. O. Dolly et al ., Biochem J. , 193 （ 1981 ）, 919 .

S. T. Yui et al ., J. Labelled Compd. Radiopharm. , 20 （ 1983 ）, 2 : 278 .

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Preparation of N-succ nimidyl (2, 3-3H) propionate

DOI：

摘要

Abstract

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Preparation of N-succ nimidyl (2, 3-³H) propionate