Selective retention in tissue cells and the chromosome aberration induced by large doses of <sup>147</sup>Pm

Siying Zheng; Shoupeng Zhu; Liuyi Wang; Guanhua Lai; Xiuying Zhao; Shuqin Yang

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Selective retention in tissue cells and the chromosome aberration induced by large doses of ¹⁴⁷Pm

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- Selective retention in tissue cells and the chromosome aberration induced by large doses of ¹⁴⁷Pm
- Nuclear Techniques Vol. 12, Issue 11, (1989)
- 作者机构：
  
  苏州医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：04 November 1987，
  
  Published：1989-11
- 稿件说明：
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Siying Zheng, Shoupeng Zhu, Liuyi Wang, et al. Selective retention in tissue cells and the chromosome aberration induced by large doses of ¹⁴⁷Pm[J]. Nuclear techniques, 1989, 12(11): 688-692.
DOI：

Siying Zheng, Shoupeng Zhu, Liuyi Wang, et al. Selective retention in tissue cells and the chromosome aberration induced by large doses of ¹⁴⁷Pm[J]. Nuclear techniques, 1989, 12(11): 688-692. DOI：

摘要

本文研究了机体摄入大剂量裂片

147

Pm后，在其选择性蓄积部位肝和骨组织细胞中诱发的染色体畸变。实验结果发现大剂量

147

Pm可诱发再生肝和骨髓细胞的染色体畸变，畸变类型以染色单体断裂为主，都在90%以上。染色体畸变率随

147

Pm摄入量的增加而增多。在同一剂量组中再生肝细胞的畸变率明显高于骨髓细胞。这与

147

Pm在各器官中沉积的放射量不同有关。其次尚可见到大剂量

147

Pm对机体有细胞毒性作用，抑制细胞的分裂活动。

Abstract

This paper presents a study on the chromosome aberrations induced by selective retention of

147

Pm in liver and bone marrow cells of BALB/C strain mice that have been injected large doses of

147

Pm. It was shown that large doses of

147

Pm induced chromosome aberrations in regenerated liver and bone marrow cells

and chromatid breakage appeared predominant. The larger the doses

the higher the chromosome aberrations. Regenerated liver cell aberrations were higher than marrow cell aberrations. At the same time the cytotoxicity induced by large dosage of

147

Pm is designable and the body cell divisions were depressed.

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references

朱寿彭等，放射毒理学，第一版，北京原子能出版社， 1983 年，第306页。

郑斯英等，核技术， 11 （ 1988 ）, 4 : 55 。

郑斯英等，中华放射医学与防护杂志， 8 ( 1988 ), 1 : 10 。

朱寿彭等，中华劳动卫生职业病杂志， 2 （ 1984 ）, 6 ： 341 。

T. Ishihara and M. Sasaki eds ., Radiation-induced chromosome damage in man , Liss , New York , 1983 , p. 111 .

T. Sugavara and O. Hug （eds） , Biological aspects of radiation protection , Springer , Berlin , 1971 , p. 81 .

G. W. Dolphin et al ., Health Phys. , 25 （ 1973 ）, 7 .

Y. Matsuda et al ., Mutation Res. , 176 （ 1987 ）, 251 .

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Related Institution

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Selective retention in tissue cells and the chromosome aberration induced by large doses of 147Pm

DOI：

摘要

Abstract

关键词

Keywords

references

Selective retention in tissue cells and the chromosome aberration induced by large doses of ¹⁴⁷Pm