The fate of 【2-<sup>14</sup>C】 carbendazol in rats

Shangren Pan; Hesheng Shao; Xinan Jing; Weiyi Li; Yingying Feng; Lanqin Yin; Qinfang Kuang

您当前的位置：

首页 >

文章列表页 >

The fate of 【2-¹⁴C】 carbendazol in rats

更新时间：2022-08-16

- The fate of 【2-¹⁴C】 carbendazol in rats
- Nuclear Techniques Vol. 12, Issue 6, (1989)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：25 August 1987，
  
  Published：1989-06
- 稿件说明：
移动端阅览
Shangren Pan, Hesheng Shao, Xinan Jing, et al. The fate of 【2-¹⁴C】 carbendazol in rats[J]. Nuclear techniques, 1989, 12(6): 376-380.
DOI：

Shangren Pan, Hesheng Shao, Xinan Jing, et al. The fate of 【2-¹⁴C】 carbendazol in rats[J]. Nuclear techniques, 1989, 12(6): 376-380. DOI：

摘要

[2-

C]多菌灵（简称（MBC）给大鼠口服后动力学计算表明，而生物半衰期分布相（

1/2

）为1.3h，排泄相（

1/2

）为4.8h。在1

—48h分布实验以肝脏内放射性含量最高，肾其次。48h内尿排出的放射性量为注入量的63%，自粪排出30%。经硅胶板薄层层析检测发现，[2-

C]多菌灵从尿中大部分以原形排出，少量为羧基化的代谢产物。

Abstract

The [2-

C] carbendazol was administered to rats 60 mg/kg PO. The biological half-life

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177326&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177332&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177329&type=

was 1.1 h and

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177335&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177338&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=34177337&type=

was 4.6 h. Radioactivities reached to the highest in liver after 48 h. The percentage of dose excreted was 63% in urine and 30% in feces within 48 h. The metabolites were checked by TLC and radioautography of the urine.

关键词

Keywords

references

R.W．马什主编，郑仲等译，内吸性杀菌剂，化学工业出版社， 1983 年，第85页。

浙江省农业科学院原子能利用研究室和上海原子核研究所，原子能农业应用， 1 （ 1980 ）, 3 : 30 。

彭武厚，化学世界， 5 （ 1980 ）， 138 。

J. A. Gardiner et al . , J . Agr . Food Chem. 22 （ 1974 ）, 3 : 419 .

邵鹤生等，核技术， 11 （ 1988 ）, 8 : 56 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The distribution and excretion of nerve growth factor in mice

Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice

Distribution and metabolic behavior of ³H-HPD in pregnant mice

Preparation, in vivo metabolism and distribution of TagS750-Cas9 nuclease

Study on distribution of different forms of tritium in grassland around Qinshan nuclear power station

Related Author

姜国辉

唐刚华

陈力真

张云

王世真

王树惠

Qian Wu

Bimei Luo

Related Institution

中国医学科学院中国协和医科

中国医学科学院中国协和医科大学基础医学研究所

WANG Shuhui

Shih-chen Wang

Guangdong Provincial Pharmaceutical Research Institute

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880647 Visits Today：174

⁰

The fate of 【2-14C】 carbendazol in rats

DOI：

摘要

Abstract

关键词

Keywords

references

The fate of 【2-¹⁴C】 carbendazol in rats