The possibility of radiation impairment of human platelets labelled with <sup>111</sup>In-oxine

Fuping Wu; S. F. Mohammad; A. Jr. Taylor

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The possibility of radiation impairment of human platelets labelled with ¹¹¹In-oxine

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- The possibility of radiation impairment of human platelets labelled with ¹¹¹In-oxine
- Nuclear Techniques Vol. 12, Issue 5, (1989)
- 作者机构：
  
  1.南京铁道医学院附属医院
  2.美国犹他大学医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：11 September 1987，
  
  Published：1989-05
- 稿件说明：
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Fuping Wu, S. F. Mohammad, A. Jr. Taylor. The possibility of radiation impairment of human platelets labelled with ¹¹¹In-oxine[J]. Nuclear techniques, 1989, 12(5): 309-313.
DOI：

Fuping Wu, S. F. Mohammad, A. Jr. Taylor. The possibility of radiation impairment of human platelets labelled with ¹¹¹In-oxine[J]. Nuclear techniques, 1989, 12(5): 309-313. DOI：

摘要

本文探讨了

111

In-oxine标记人血小板时对血小板辐射损伤的可能性。高放射剂量组和低放射剂量组

111

In-oxine标记的血小板的体外ADP激发聚集功能均正常，且标记的自体血小板静脉注射后，仍能在血循环中维持正常功能。两组结果间无显著性差异。本文结果提示高放射性

111

In-oxine对血小板功能无辐射损伤效应。

Abstract

Investigation on the possibility of radiation impairment of human platelets labelled with

111

In-oxine has been described. 20 normal volunteers were divided into one high-radioactivity-labelled group (15.5±1.4 MBq) /10

platelets

n=10) and one low-radioactivity-labelled group (2.55±0.10 MBq/10

platelets

n=10) . The ADP-induced aggregability of

111

In-oxine-labelled platelets in-vitro was normal and the functions of

111

In-oxine-labelled platelets in vivo circulation after reinjection remained unaltered in both groups. No significant difference was found between the two groups. The results indicate that high radioactivity of

111

In-oxine does not impair the platelet function.

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Keywords

references

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W. L. Nichols et al . , Recent advances in blood coagulation, No. 3 , Churchill Livingstone , New York , 1981 .

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The possibility of radiation impairment of human platelets labelled with 111In-oxine

DOI：

摘要

Abstract

关键词

Keywords

references

The possibility of radiation impairment of human platelets labelled with ¹¹¹In-oxine