Determination of antipsychotic drug in human serum by radioreceptor assay

Jinchang Wu; Yimin Jiang

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Determination of antipsychotic drug in human serum by radioreceptor assay

更新时间：2022-08-16

- Determination of antipsychotic drug in human serum by radioreceptor assay
- Nuclear Techniques Vol. 12, Issue 5, (1989)
- 作者机构：
  
  苏州医学院附属第一医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：06 October 1987，
  
  Published：1989-05
- 稿件说明：
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Jinchang Wu, Yimin Jiang. Determination of antipsychotic drug in human serum by radioreceptor assay[J]. Nuclear techniques, 1989, 12(5): 314-316.
DOI：

Jinchang Wu, Yimin Jiang. Determination of antipsychotic drug in human serum by radioreceptor assay[J]. Nuclear techniques, 1989, 12(5): 314-316. DOI：

摘要

本文采用放射受体分析（RRA）法，检测了50例精神病患者血清中抗精神病药物的浓度，并与氯丙嗪（CPZ）放射免疫分析（RIA）法作了平行对照。结果表明：RRA测定平均值低于RIA测定平均值，但均与口服CPZ剂量呈相关性。此外，RRA和RIA之间亦存在一定的相关性。

Abstract

Serum antipsychotic drug in 50 psychosis cases were measured by radioreceptor assay (RRA) and the values were compared in parallel with that by radioimmunoassay (RIA) . The results showed that the RRA values were lower than the RIA values

but both assays gave significant correlation between the serum drug level and antipsychotic dose.

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Keywords

references

I. Creese and S. H. Snyder , Nature , 270 （ 1977 ), 180 .

江一民和吴锦昌，中华核医学杂志， 8 （ 1988 ）， 1 : 18 。

L. E. Tune et al . , J . Nerv, Ment. Dis. , 169 （ 1981 ）, 60 .

R. B. Mailman et al . , Life Sci. , 34 （ 1984 ）, 1057 .

B. M. Cohen et al . , Neuropharmacology , 19 （ 1980 ）, 663 .

M. Linnoila et al . , Acta Pharmacal. Toxicol. , 50 （ 1982 ）, 25 .

李霄凌等，中华核医学杂志 , 5 （ 1985 ）， 196 。

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