Cyclotron production of thallous chloride <sup>201</sup>T1 injection

Chuanpeng Wang; Jiading Zhang; Tingwen Rong; Xiaofeng Lu; Qixun Sun; Weiyu He; Zhaoyi Zhao; Zongzhi Huang; Xingen Yu; Lanping Yang; Shouqing Weng; Hongdi Zhou; Jiong Zhang; Defeng Xie; Qianmei Ji; Yunxia Lan; Bin Jiang; Binghua Xie

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Cyclotron production of thallous chloride ²⁰¹T1 injection

更新时间：2022-08-16

- Cyclotron production of thallous chloride ²⁰¹T1 injection
- Nuclear Techniques Vol. 12, Issue 5, (1989)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：07 October 1987，
  
  Published：1989-05
- 稿件说明：
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Chuanpeng Wang, Jiading Zhang, Tingwen Rong, et al. Cyclotron production of thallous chloride ²⁰¹T1 injection[J]. Nuclear techniques, 1989, 12(5): 263-266.
DOI：

Chuanpeng Wang, Jiading Zhang, Tingwen Rong, et al. Cyclotron production of thallous chloride ²⁰¹T1 injection[J]. Nuclear techniques, 1989, 12(5): 263-266. DOI：

摘要

本文叙述制备放射性氯化亚铊（

201

T1）注射液的方法。靶子为高纯金属铊片，装于具有水冷、气冷腔的2

靶室内，利用扇形聚焦回旋加速器所产生的30MeV质子进行辐照。靶片溶解后，联合使用液－液萃取和阴离子交换法进行化学处理，可同时获得无载体

203

Pb。产品

201

T1核纯度大于99%（

200

T1～0.76%

202

T1～0.04%），放化纯度大于98%，含铊量小于0.27×10

-7

µg/Bq（1.0µg/mCi）

201

T1，化学杂质Fe、A1等均小于1ppm，

201

T1厚靶产额约为18.8MBq/µAh。产品经临床前药理试验、药检试验和临床试用，质量良好。

Abstract

The production of thallous chloride

201

T1 injection is described.

201

T1 was produced via nuclear reaction of

203

T1 (p

)

201

Pb. using natural thallium in a specially designed 2

cooling target system. The separation of Pb-activity from the T1 target was carried out by extraction of T1 (Ⅲ) with isopropyl ether and purification of Pb (Ⅱ) with an anion exchanger (201×8 resin) column. After a decay time of 32h

during which an optimum growth of

201

T1 took place

carrier-free

201

T1 was separated from the

203

Pb activities by a second similar anion exchanger. Dependences of the percentage extraction of T1 (Ⅲ) from HC1 solution into isopropyl ether on acidity and concentration of T1 (Ⅲ) in aqueous phase were determined. The thick target yield of

201

T1 is 18.8MBq/µAh. The product possesses a radioisotopic purity of

99% and a radiochemical purity of

98%It is a sterile

isotonic and pyrogen-free solution with a T1 content of 0.27×10

-7

µg/Bq.

关键词

Keywords

references

E. Lebowits et al . , J. Nucl. Med. , 16 （ 1975 ）, 151 .

M. C. Lagunas-Solar et al . , J . Label. Comp. Radiopharm. , 3 （ 1977 ）, 189 .

S. M. Qaim et al . , Int. J. Appl. Radiat. Isotopes , 30 （ 1979 ）, 85 .

孙祺薰等，核技术， 10 （ 1986 ）, 4 : 40 。

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Cyclotron production of thallous chloride 201T1 injection

DOI：

摘要

Abstract

关键词

Keywords

references

Cyclotron production of thallous chloride ²⁰¹T1 injection