Applications of NMR in biological metabolic research

Jiarui Nie; Xiuqin Li; Chunjian He

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Applications of NMR in biological metabolic research

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- Applications of NMR in biological metabolic research
- Nuclear Techniques Vol. 12, Issue 5, (1989)
- 作者机构：
  
  1.郑洲大学
  2.开封市第一人民医院
  3.河南医科大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：11 December 1987，
  
  Published：1989-05
- 稿件说明：
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Jiarui Nie, Xiuqin Li, Chunjian He. Applications of NMR in biological metabolic research[J]. Nuclear techniques, 1989, 12(5): 253-258.
DOI：

Jiarui Nie, Xiuqin Li, Chunjian He. Applications of NMR in biological metabolic research[J]. Nuclear techniques, 1989, 12(5): 253-258. DOI：

摘要

核磁共振已成为生物代谢研究的有力手段。它是完全非侵入、无损伤的探测方法。因此能够在生理条件下，在分子水平上研究生物体的代谢过程，所以它优于其他传统方法。

利用NMR的重要参数——化学位移、纵向弛豫时间及横向弛豫时间，可以对代谢过程和反应物及产物的结构、浓度、输运和分布等进行观测和跟踪。

H、

P和

C等核的NMR谱已广泛用于代谢研究。

Abstract

The nuclear magnetic resonance has become a powerful means of studying biological metabolism in non-invasive and non-destructive way. Being used to study the metabolic processes of living system in normal physiological conditions as well as in molecular level

the method is better than other conventional approaches.

Using important parameters such as NMR-chemical shifts

longitudinal relaxation time and transverse relaxation time

it is possible to probe the metabolic processes as well as conformation

concentration

transportation and distribution of reacting and resulting substances. The NMR spectroscopy of

P and

C nuclei has already been widely used in metabolic researches.

关键词

Keywords

references

R. A. Iles et al . , Prog. NMR Spectrosc. , 15 （ 1982 ）, 49 .

D. G. Gadian , NMR and its applications to living systems , Oxford University Press , Oxford , 1982 .

G. M. Bydder , Brit. Med. Bull. , 40 （ 1984 ）, 170 .

J. R. Griffiths et al . , The Lancet , （ 1983 ）, 1 : 1435 .

A. A. Maudsley et al . , Brit. Med. Bull. , 40 （ 1984 ）, 165 .

I. D. Campbell et al . , Meth. Biochem. Anal. , 25 （ 1979 ）, 1 .

R. V. Nanda et al . , J. Magn. Reson. , 39 （ 1980 ）, 119 .

P. A. Bottomley et al . , The Lancet , （ 1983 ）, 2 : 273 .

P. A. Bottomley et al . , Radiology. , 150 （ 1984 ）, 441 .

D. P.Brenton et al . , The Lancet , （ 1985 ）, 1 : 115 .

L. Mueller , J . Am . Chem. Soc. , 101 （ 1979 ）, 448 .

L. Mueller et al . , J. Magn. Reson. , 66 （ 1986 ）, 379 .

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