Imaging of liver cancer in liver cancer bearing rats using anti-AFP monoclonal antibodies

Yaozhang Huang; Yongxin Wang; Xiaochun Wang; Fuqi Wang; Jialing Huang; Quanhai Liu

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Imaging of liver cancer in liver cancer bearing rats using anti-AFP monoclonal antibodies

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- Imaging of liver cancer in liver cancer bearing rats using anti-AFP monoclonal antibodies
- Nuclear Techniques Vol. 12, Issue 3, (1989)
- 作者机构：
  
  1.上海市第一人民医院
  2.中国科学院上海细胞生物研究所
  3.上海市医药工业研究院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：01 July 1987，
  
  Published：1989-03
- 稿件说明：
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Yaozhang Huang, Yongxin Wang, Xiaochun Wang, et al. Imaging of liver cancer in liver cancer bearing rats using anti-AFP monoclonal antibodies[J]. Nuclear techniques, 1989, 12(3): 185-188.
DOI：

Yaozhang Huang, Yongxin Wang, Xiaochun Wang, et al. Imaging of liver cancer in liver cancer bearing rats using anti-AFP monoclonal antibodies[J]. Nuclear techniques, 1989, 12(3): 185-188. DOI：

摘要

将

125

I标记抗AFP McAb（3.7MBq/1mg/0.3ml），静脉注入带肝癌鼠模型（wistar及裸鼠），24、48、72小时后进行

照相。在移植肝癌的部位可见放射性浓聚的“阳性区”。而注入

125

I-正常小鼠IgG的对照鼠，在肝癌部位未见放射性浓集，也未见肿瘤显像。

Abstract

125

I-labelled anti-AFP McAb IgG and normal mouse IgG were prepared and evaluated by radioimmunoimaging of a chemical induced liver cancer bearing rat and a human liver cancer xenografted nude mice. The imaging were made with a gamma camera at 24

48 and 72 h after intravenous injection of 3.7×10

Bq of

125

I-anti-AFP McAb containing lmg of IgG into each tumor-bearing animal. The accumulation of anti-AFP McAb in tumor was indicated but not with the same dose of

125

I-normal mouse IgG.

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references

上海市第一人民医院，中华肿瘤杂志，（ 1982 ）， 2 : 127 。

平井秀松，他， Radioisotopes , 33 （ 1984 ）, 7 : 474 .

E. E. Rim et al . , Cancer Res . , （ 1980 ）, 40 : 3008 .

D. M. Goldenberg et al . , Cancer , 1980 , 45 : 2500 .

S. M. Larson ., J . Nucl. Med . , （ 1985 ）, 26 : 538 .

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