Synthesis of NCL-6-Et<sup>82</sup>Br and its distribution in mouse's organs

Boli Liu; shiping Chen; Taihua Li; Yutai Jin; M. Kojima; M. Maeda; T. Kobayashi

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Synthesis of NCL-6-Et⁸²Br and its distribution in mouse's organs

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- Synthesis of NCL-6-Et⁸²Br and its distribution in mouse's organs
- Nuclear Techniques Vol. 12, Issue 1, (1989)
- 作者机构：
  
  1.北京师范大学应用化学研究所
  2.日本九州大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：25 May 1987，
  
  Published：1989-01
- 稿件说明：
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Boli Liu, shiping Chen, Taihua Li, et al. Synthesis of NCL-6-Et⁸²Br and its distribution in mouse's organs[J]. Nuclear techniques, 1989, 12(1): 54-57.
DOI：

Boli Liu, shiping Chen, Taihua Li, et al. Synthesis of NCL-6-Et⁸²Br and its distribution in mouse's organs[J]. Nuclear techniques, 1989, 12(1): 54-57. DOI：

摘要

本文采用冠醚法和湿热法标记了化合物

Br-6-溴乙基-19-去甲胆固醇（NCL-6-Et

Br）

研究了这种标记物在小白鼠体内的生物分布。结果表明，它在肾上腺组织的吸收量明显高于CL-6-

Br和NCL-6-

Br；肾上腺／肝和肾上腺／肾比值均高于CL-6-

Br，而与NCL-6-

Br相近。

Abstract

Bromine-82 labelled 6

- (2'-bromo) ethyl-19-norcholest-5 (10) -en-3

-ol (i. e. NCL -6-Et

Br) has been prepared both by the crown ether method and by the hydrothermal melting method. A study on its distribution in mouse's organs showed a rather selectiver localization of radioactivity in adrenal gland

in which the absorption of NCL-6-Et-

Br was found to be higher than that of CL-6-

Br or NCL-6-

Br. The adrenal/liver and adrenal/ hidney ratios of the titled compound were shown to be higher than those of CL-6-

and near those of NCL-6-

Br.

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Keywords

references

V. H. T. James ed. , The adrenal gland , Raven Press , New York , 1979 , p. 309 .

G. V. S Rayudu ed. , Radiotracers for medical applications , CRC Press Inc. , Boca Raton , Vol. I , Chap, 7 , 1983 , p. 36 .

刘伯里等，核化学与放射化学， 2 （ 1980 ）， 107 。

潘中允等，中华核医学杂志， 1 （ 1981 ）, 2；85 。

M. Kojima et al . , Chem. Pharm. Bull. , 35 （ 1987 ）, 5 : 2101 .

H. Komatsu et al . , Synthesis , 36 （ 1977 ）.

T. Kobayashi et al . , Steroids , 39 （ 1982 ）, 585 .

刘伯里等，核化学与放射化学， 7 （ 1985 ）, 29 。

Liu B. L. et al . , Radioisotopes , 30 （ 1981 ）, 391 .

M. Kojima et al . , Steroids , 29 （ 1977 ）, 443 .

Liu B. L. et al . , J. Lab. Comp. Radiopharm , 19 （ 1982 ）, 1089 .

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Shiping Chen

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Synthesis of NCL-6-Et82Br and its distribution in mouse's organs

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis of NCL-6-Et⁸²Br and its distribution in mouse's organs