Reversed-phase high-performance liquid chromatographic investigation on the relationship between structure and in-vivo distribution of hepatobiliary agents

Wendi Ding; Yulin Hu; Renbin Zhang; Yuyuan Xie; Maosong Jiang; Meichu Luo; Chuanfen Xu

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Reversed-phase high-performance liquid chromatographic investigation on the relationship between structure and in-vivo distribution of hepatobiliary agents

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- Reversed-phase high-performance liquid chromatographic investigation on the relationship between structure and in-vivo distribution of hepatobiliary agents
- Nuclear Techniques Vol. 11, Issue 4, (1988)
- 作者机构：
  
  1.中国科学院上海药物研究所
  2.华东医院
  3.上海放射医学研究所
  4.上海木材研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-04
- 稿件说明：
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Wendi Ding, Yulin Hu, Renbin Zhang, et al. Reversed-phase high-performance liquid chromatographic investigation on the relationship between structure and in-vivo distribution of hepatobiliary agents[J]. Nuclear techniques, 1988, 11(4): 50-54.
DOI：

Wendi Ding, Yulin Hu, Renbin Zhang, et al. Reversed-phase high-performance liquid chromatographic investigation on the relationship between structure and in-vivo distribution of hepatobiliary agents[J]. Nuclear techniques, 1988, 11(4): 50-54. DOI：

摘要

本工作用两种C

反相色谱系统测定了36个取代的苯胺甲酰甲基亚氨二乙酸类化合物的log

'值，考察了不同位置取代的配体的log

'值与它们的理论疏水性

∑π

值之间的关系，研究了配体的log

'值与它的标记物在肝胆和小肠中分布的浓度和关系，并讨论了药物在肝内转移速度的影响因素。

Abstract

Two C

reversed-phase chromatographic systems were used to determine the log

' values of thirty-six substituted acetanilido-iminoacetic acids. The relationship between log

' values of ligands with substituents in different positions and their theoretical hydrophobicities

∑π

was examined. The relationship between log

' values of ligands and the distribution of their labelled complexes in liver

gallbladder and small intestine was investigated. The factors affecting hepatocellular transit rate of drugs were discussed

关键词

Keywords

references

E. Harvey et al . , J. Nucl. Med. , 16 ( 1975 ), 533 .

W. H. Fishman , Metabolic Conjugation and metabolic hydrolysis , Vol.2 , New York , 1970 , p. 1 .

P. Nielsen et al . , Life Sci. , 17 ( 1975 ), 1495 .

G. Subramanian et al . , J. Nucl. Med. , 18 ( 1977 ), 624 .

A. D. Nunn et al . , J. Nucl. Med. , 24 ( 1983 ), 423 .

胡玉麟等，药学学报， 18 （ 1983 ）， 9 ： 678 。

蒋茂松等，上海市原子核学会1984年年会论文摘要汇编，p. 105 。

J. M. McCall , J. Med. Chem. , 18 ( 1975 ), 549 .

T. Yamana et al . , J. Pharm. Sci. , 66 ( 1977 ), 747 .

Leo A Hansch C. , Substituent constants for correlation analysis in chemistry and biology. , New York , Wiley , 1979 .

M. Molter et al . , J. Lab. Comp. Radiopharm. , 18 ( 1981 ), 57 .

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