Study on pharmacokinetics of fibrinolytic enzyme of trimeresurus mucrosqamatu's venom in vivo

Tingen Dai; Feng Wang; Songbai Huang

您当前的位置：

首页 >

文章列表页 >

Study on pharmacokinetics of fibrinolytic enzyme of trimeresurus mucrosqamatu's venom in vivo

更新时间：2022-08-16

- Study on pharmacokinetics of fibrinolytic enzyme of trimeresurus mucrosqamatu's venom in vivo
- Nuclear Techniques Vol. 11, Issue 1, (1988)
- 作者机构：
  
  成都军区昆明总医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-01
- 稿件说明：
移动端阅览
Tingen Dai, Feng Wang, Songbai Huang. Study on pharmacokinetics of fibrinolytic enzyme of trimeresurus mucrosqamatu's venom in vivo[J]. Nuclear techniques, 1988, 11(1): 59.
DOI：

Tingen Dai, Feng Wang, Songbai Huang. Study on pharmacokinetics of fibrinolytic enzyme of trimeresurus mucrosqamatu's venom in vivo[J]. Nuclear techniques, 1988, 11(1): 59. DOI：

摘要

本文报道用氯胺T法

125

I标记的烙铁头蛇毒纤溶组分在小鼠和兔子体内的药代动力学研究。结果表明小鼠肌注后在血液和各脏器中分布达到高峰值时间为30min，1h开始下降，2h左右达到平衡后出现缓慢的消除相，各主要脏器及血液之间的比是：肾＞血＞肝＞肺＞肌肉＞脾，分布相半衰期

为0.64h，消除相半衰期

为12.16h，表明在小鼠体内消除较慢，维持时间长。兔子耳静脉注射

125

I标记的纤溶组分后分布相半衰期

为0.34h，从中央室向周边室分布都很迅速，消除相半衰期

为6.88h，结果同样表明在兔子体内消除较慢，维持时间较长，二者药代动力学变化符合开放两室模型。

Abstract

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The preparation and biodistribution of ⁹⁹Tc^m-EIDP

Pharmacokinetic studies on ￣（99m）Tc（V ）-DMSA in rats

Preparation and pharmacometabolic experiment of ￣（125）Ⅰ- rhG- CSF

Related Author

NIU Guosai1

2 LUO Shineng2

1 YAN Xiaohong1

2 YANG Min2 YE Wanzhong2 XIA Yongmei1 1

叶万忠

王洪勇

夏咏梅

颜学先

Related Institution

School of Chemical and material Engineering, Southern Yangtze University, Wuxi 214122,China) 2

江苏省原子医学研究所卫生部核医学重点实验室

Chongqing University of Medical Sciences

Second Military Medical University, Shanghai 200433)Deng Zhongping

Jiang Jianqiang

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880565 Visits Today：92

⁰