Distribution and excretion of 8-<sup>3</sup>H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice

Bimei Luo; Rong Liu; Qian Wu; Xianglan Huang; Ning Chen

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Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice

更新时间：2022-08-16

- Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice
- Nuclear Techniques Vol. 11, Issue 1, (1988)
- 作者机构：
  
  广东省药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-01
- 稿件说明：
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Bimei Luo, Rong Liu, Qian Wu, et al. Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice[J]. Nuclear techniques, 1988, 11(1): 57-58.
DOI：

Bimei Luo, Rong Liu, Qian Wu, et al. Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice[J]. Nuclear techniques, 1988, 11(1): 57-58. DOI：

摘要

阿糖腺苷（Ara-A）是一种安全有效的抗DNA病毒药物，主要用于治疗单纯疱疹性角膜炎等。近年来国内外医药界越来越重视其对慢性乙型病毒性肝炎的治疗作用，但Ara-A在水中溶解度小（0.45mg/ml）、临床用作静脉滴注时间长，使用不便。国外文献报道在Ara-A众多的衍生物中，Ara-Amp是一种用于肌肉和静脉注射的有前途的新抗病毒药。Ara-Amp是Ara-A的前体药物，溶解度大、进入血液后很快脱磷生成Ara-A，为了研究Ara-Amp在体内分布排泄情况，本文用放射性氚标记单磷酸阿糖腺苷（8-

H-Ara-Amp）作示踪剂进行实验。

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Distribution and excretion of 8-3H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice

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Distribution and excretion of 8-³H-9-B-D-arabinofuranosyl adenine 5'-phosphate in mice