Calculation of and comment on the internal radiation absorption dose of brainblood flow imaging agents 99mTc-HMPAO, 123I-HIPDM and 131I-HIPDM

Zhongyun Pan; Shaowei Jia; Shaoli Zhu; Yanjun Xue; Beisheng Wu; Shitian Liang

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Calculation of and comment on the internal radiation absorption dose of brainblood flow imaging agents ^99mTc-HMPAO, ¹²³I-HIPDM and ¹³¹I-HIPDM

更新时间：2022-08-16

- Calculation of and comment on the internal radiation absorption dose of brainblood flow imaging agents ^99mTc-HMPAO, ¹²³I-HIPDM and ¹³¹I-HIPDM
- Nuclear Techniques Vol. 11, Issue 1, (1988)
- 作者机构：
  
  北京医科大学第一医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-01
- 稿件说明：
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Zhongyun Pan, Shaowei Jia, Shaoli Zhu, et al. Calculation of and comment on the internal radiation absorption dose of brainblood flow imaging agents ^99mTc-HMPAO, ¹²³I-HIPDM and ¹³¹I-HIPDM[J]. Nuclear techniques, 1988, 11(1): 56.
DOI：

Zhongyun Pan, Shaowei Jia, Shaoli Zhu, et al. Calculation of and comment on the internal radiation absorption dose of brainblood flow imaging agents ^99mTc-HMPAO, ¹²³I-HIPDM and ¹³¹I-HIPDM[J]. Nuclear techniques, 1988, 11(1): 56. DOI：

摘要

用MIRD法及自编程序计算了

99m

Tc-HMPAO、

123

I-HIPDM和

131

I-HIPDM的内照射辐射吸收剂量。结果表明：即使甲状腺未封闭，

99m

Tc-HMPAO和

123

I-HIPDM一次剂量（分别为185MBq及555MBq）全身和各脏器的吸收剂量也皆低于10

-2

Gy，无疑是安全的。但37MBq的

131

I-HIPDM在未封闭甲状腺时，睾丸、肝和肺的吸收剂量即等于或近于10

-2

Gy，甲状腺吸收剂量已达2×10

-2

Gy。事先封闭甲状腺，37MBq的

131

I-HIPDM全身和各脏器的吸收剂量也稍多于

99m

Tc-HMPAO和

124

I-HIPDM的一次用量。因此，

131

I-HIPDM的一次检查用量不可能增加很多，加上

131

I的物理性能不适当，难以用于脑血流

照相和断层显像。能否在用量为37MBq以内应用扫描机对脑血流作粗略的显像观察，有待临床试验。

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